| URN | urn:agi-llid:9314 |
|---|---|
| Connectivity | 242 |
| Name | KLF4 |
| Description | Kruppel-like factor 4 (gut) |
| Notes | a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene [RGD] |
| Pathway | PPARG Targets |
|---|
| Ariadne Ontology | KLF |
|---|
| GO Molecular Function | nucleic acid binding |
|---|---|
| metal ion binding | |
| zinc ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| double-stranded DNA binding | |
| transcription activator activity | |
| transcription repressor activity | |
| RNA polymerase II transcription factor activity |
| GO Cellular Component | intracellular |
|---|---|
| nucleus | |
| transcription factor complex | |
| chromatin |
| GO Biological Process | mesodermal cell fate determination |
|---|---|
| negative regulation of cell proliferation | |
| stem cell maintenance | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of cell proliferation | |
| regulation of transcription, DNA-dependent | |
| cell differentiation | |
| epidermal cell differentiation | |
| transcription | |
| post-embryonic camera-type eye development | |
| epidermis morphogenesis | |
| response to chemical stimulus | |
| response to retinoic acid |
| Group | KLF |
|---|---|
| intracellular | |
| nucleus | |
| transcription factor complex | |
| chromatin | |
| nucleic acid binding | |
| metal ion binding | |
| zinc ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| double-stranded DNA binding | |
| transcription activator activity | |
| transcription repressor activity | |
| RNA polymerase II transcription factor activity | |
| mesodermal cell fate determination | |
| negative regulation of cell proliferation | |
| stem cell maintenance | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of cell proliferation | |
| regulation of transcription, DNA-dependent | |
| cell differentiation | |
| epidermal cell differentiation | |
| transcription | |
| post-embryonic camera-type eye development | |
| epidermis morphogenesis | |
| response to chemical stimulus | |
| response to retinoic acid |
| Hugo ID | 6348 |
|---|
| Human chromosome position | 9q31 |
|---|
| LocusLink ID | 9314 |
|---|---|
| 16600 | |
| 114505 |
| Alias | EZF |
|---|---|
| GKLF | |
| Kruppel-like factor 4 (gut) | |
| OTTHUMP00000021862 | |
| endothelial Kruppel-like zinc finger protein | |
| Zie | |
| RP23-322L22.2 | |
| Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF) | |
| MGC93286 | |
| KLF4 | |
| Kruppel-like factor 4 | |
| Kruppel-like factor IV | |
| Epithelial zinc-finger protein EZF | |
| LOC230221 | |
| LOC269540 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602253 |
|---|
| Swiss-Prot Accession | O43474 |
|---|---|
| Q5T3J6 | |
| Q60793 | |
| Q923V7 |
| Unigene ID | Hs.376206 |
|---|---|
| Mm.4325 | |
| Rn.7719 |
| KEGG ID | rno:114505 |
|---|
| Swiss-Prot ID | KLF4_HUMAN |
|---|---|
| KLF4_MOUSE | |
| Q923V7_RAT |
| Cell Localization | Nucleus |
|---|
| GO ID | 0046872 |
|---|---|
| 0043565 | |
| 0016563 | |
| 0003700 | |
| 0016564 | |
| 0008270 | |
| 0009913 | |
| 0007500 | |
| 0008285 | |
| 0045892 | |
| 0045944 | |
| 0031077 | |
| 0042221 | |
| 0032526 | |
| 0019827 | |
| 0006350 | |
| 0005622 | |
| 0005634 | |
| 0003677 | |
| 0003676 | |
| 0030154 | |
| 0048730 | |
| 0042127 | |
| 0006355 | |
| 0003702 | |
| 0003690 | |
| 0048662 | |
| 0000785 | |
| 0005667 |
| IPI ID | IPI00643479 |
|---|---|
| IPI00012531 | |
| IPI00167069 | |
| IPI00640893 | |
| IPI00874650 | |
| IPI00120384 | |
| IPI00326010 |
| Mouse chromosome position | 4 19.7 cM |
|---|
| Homologene ID | 3123 |
|---|
| MGI ID | 1342287 |
|---|
| Rat chromosome position | 5q24 |
|---|
| RGD ID | 621445 |
|---|