| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:7351::positive |
|---|---|
| References | 10 |
| Connectivity | 2 |
| Effect | positive |
| TextRef | info:pmid/9832429#abs:15 |
|---|---|
| Organ | liver |
| MedLine Reference | 9832429:14 |
| Sentence | PPAR alpha activation in mice is sufficient to induce liver UCP-2 expression. |
| TextRef | info:pmid/15356383#abs:9 |
|---|---|
| Organ | liver |
| MedLine Reference | 15356383:8 |
| Sentence | We thus conclude that the PPAR-alpha-mediated effects of BF on the expression of liver UCP2 may be one of the factors that helped to decrease insulin levels. |
| TextRef | info:pmid/16782780#abs:9 |
|---|---|
| MedLine Reference | 16782780:8 |
| Sentence | This study shows that PPARalpha activation can upregulate UCP-2 expression, which in turn enhances cyanide-induced necrotic cell death through an increase of mitochondrial dysfunction. |
| TextRef | info:pmid/11782473#abs:10 |
|---|---|
| MedLine Reference | 11782473:9 |
| Sentence | These data indicate that PPARalpha activators up-regulate UCP2 expression in hepatocytes through unknown proteins by increased transcription, and neither ROS nor TNFalpha production are the major causes for PPARalpha activators-induced UCP2 up-regulation. |
| CellType | hepatocyte |
| Organism | Rodentia |
|---|---|
| TextRef | info:pmid/11259402#abs:2 |
| Organ | heart |
| MedLine Reference | 11259402:1 |
| Sentence | We investigated in the adult rodent heart 1) whether changes in workload, substrate supply, or cytokine (TNF-alpha) administration affect UCP-2 and UCP-3 expression, and 2) whether peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the expression of either UCP-2 or UCP-3. |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/11289045#cont:195 |
| MedLine Reference | 11289045:10194 |
| Sentence | The UCP2 promoter contains a PPAR response element ( 37 ). |
| Journal | Diabetes |
| Journal Reference | v50 i4 p803 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/50/4/803 |
| CellLineName | INS-1 cell |
|---|---|
| TextRef | info:pmid/12032169#cont:192 |
| MedLine Reference | 12032169:10191 |
| Sentence | PPARa induces UCP2 expression in INS-1 cells. |
| Journal | Lipid Res |
| Journal Reference | v43 i6 p936 |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/936 |
| TextRef | info:pmid/15514275#cont:172 |
|---|---|
| Organ | liver |
| MedLine Reference | 15514275:10171 |
| Sentence | In fact, a PPAR response element was identified in the UCP promoter region ( 33 , 34 ), and PPARa activation in mice is sufficient to induce liver UCP-2 expression ( 35 ). |
| Journal | Nutrition |
| Journal Reference | v134 i11 p3054 |
| Journal Link | http://jn.nutrition.org/cgi/content/full/134/11/3054 |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | islet |
| TextRef | info:pmid/11897694#cont:196 |
| Organ | pancreas |
| MedLine Reference | 11897694:10195 |
| Sentence | In support of such a notion, the UCP-2 promoter contains a PPAR response element ( 25 ), and the PPAR gamma activator troglitazone has been found to increase UCP2 expression in rat pancreatic islets ( 26 ). |
| Journal | Endocrinology |
| Journal Reference | v143 i4 p1371 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/4/1371 |
| TextRef | info:pmid/14525954#cont:189 |
|---|---|
| MedLine Reference | 14525954:10188 |
| Sentence | The significance, and specificity of the UCP-1 to -3 response by cotreatment with PPARß/delta and RXR agonists, are further highlighted by the observation that the cotreatment with the agonists for PPARalpha and -gamma in the presence of an RXR agonist relatively poorly induced UCP-2 and -3 mRNA expression (Fig. 4G ). |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i12 p2477 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/12/2477 |