| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:26291::positive |
|---|---|
| References | 6 |
| Connectivity | 2 |
| Effect | positive |
| TextRef | info:pmid/18680716#abs:1 |
|---|---|
| MedLine Reference | 18680716:0 |
| Sentence | FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. |
| TextRef | info:pmid/17550777#abs:3 |
|---|---|
| Organ | liver |
| MedLine Reference | 17550777:2 |
| Sentence | FGF21 is induced directly by PPARalpha in liver in response to fasting and PPARalpha agonists. |
| Organism | Homo sapiens |
|---|---|
| TextRef | info:pmid/17601491#abs:7 |
| Organ | liver |
| MedLine Reference | 17601491:6 |
| Sentence | Further studies on the mechanisms of regulation of FGF21 by PPARalpha in humans will be of great interest. |
| CellType | hepatocyte |
| TextRef | info:pmid/17954559#cont:549 |
|---|---|
| MedLine Reference | 17954559:10548 |
| Sentence | Endocrine regulation of the fasting response by PPARa-mediated induction of fibroblast growth factor 21. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v28 i1 p188 |
| Journal Link | http://mcb.asm.org/cgi/content/full/28/1/188 |
| CellLineName | SA |
|---|---|
| TextRef | info:pmid/18469201#cont:266 |
| MedLine Reference | 18469201:10265 |
| Sentence | J Biol Chem 277:24484-24489, 2002 [Abstract/ Free Full Text] Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA: Endocrine regulation of the fasting response by PPAR-alpha-mediated induction of fibroblast growth factor 21. |
| Journal | Diabetes |
| Journal Reference | v57 i8 p2012 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/57/8/2012 |
| CellLineName | SA |
|---|---|
| TextRef | info:pmid/18252893#cont:263 |
| MedLine Reference | 18252893:10262 |
| Sentence | Biochem Biophys Res Commun 360:437-440, 2007 [CrossRef] [Medline] Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. |
| Journal | Diabetes |
| Journal Reference | v57 i5 p1246 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/57/5/1246 |