| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:6319::unknown |
|---|---|
| References | 4 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/15199412#cont:277 |
|---|---|
| Organ | liver |
| MedLine Reference | 15199412:10276 |
| Sentence | SCD1 expression is positively regulated by SREBP1c, C/EBPa, and PPARa ( 56 , 57 ) but negatively regulated by PPAR? ligands ( 58 ). |
| Journal | J Clin Invest |
| Journal Reference | v113 i12 p1774 |
| Journal Link | http://www.jci.org/cgi/content/full/113/12/1774 |
| CellType | hepatocyte |
| TextRef | info:pmid/10484602#cont:190 |
|---|---|
| MedLine Reference | 10484602:10189 |
| Sentence | We hypothesized that PUFA-activated PPAR, along with its heterodimeric partner retinoic acid X receptor (RXR), might repress SCD1 gene transcription. |
| Journal | Lipid Res |
| Journal Reference | v40 i9 p1549 |
| Journal Link | http://www.jlr.org/cgi/content/full/40/9/1549 |
| CellType | adipocyte |
| TextRef | info:pmid/12736163#cont:151 |
|---|---|
| Organ | liver |
| MedLine Reference | 12736163:10150 |
| Sentence | PPARalpha also regulates the expression of SCD1, which mainly converts palmitic acid and stearic acid to their monounsaturated forms ( 36 ). |
| Journal | Endocrin. Metabol |
| Journal Reference | v285 i3 pE504 |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/285/3/E504 |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/16459312#cont:215 |
| Organ | liver |
| MedLine Reference | 16459312:10214 |
| Sentence | We suggest that p/CIP and SRC-1 may exert direct effects on SCD1 expression by interacting with PPARthe PPAR-responsive site ( Miller and Ntambi, 1996 ) in the promoter of the SCD1 gene. |