| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:5106::positive |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | positive |
| TextRef | info:pmid/16543372#cont:192 |
|---|---|
| Organ | liver |
| MedLine Reference | 16543372:10191 |
| Sentence | PPARa also enhances hepatic gluconeogenesis by increasing PEPCK and G6Pase expression ( 21 , 22 ). |
| Journal | Endocrinology |
| Journal Reference | v147 i6 p3060 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/147/6/3060 |
| TextRef | info:pmid/11399762#cont:53 |
|---|---|
| MedLine Reference | 11399762:10052 |
| Sentence | In hepatocytes, gAF1/PCK1 is bound by a variety of nuclear receptors including COUP-TFs, HNF4, RAR/RXR, and PPARalpha that activate the PEPCK promoter ( 39-41 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i32 p30561 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/32/30561 |
| CellType | hepatocyte |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/10359558#cont:309 |
| MedLine Reference | 10359558:10308 |
| Sentence | This is surprising considering that the PEPCK promoter contains an intermediate-affinity PPAR response element ( 43 ), which is responsible for the upregulation of PEPCK by PPAR? in adipose tissue ( 38 ). |
| Journal | J Clin Invest |
| Journal Reference | v103 i11 p1489 |
| Journal Link | http://www.jci.org/cgi/content/full/103/11/1489 |