| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:1375::positive |
|---|---|
| References | 7 |
| Connectivity | 2 |
| Effect | positive |
| TextRef | info:pmid/19233164#abs:8 |
|---|---|
| Organ | heart |
| MedLine Reference | 19233164:7 |
| Sentence | The occupation of PPAR-alpha and MEF-2A consensus sites in the CPT-1B promoter was measured using chromatin immunoprecipitation assays. |
| TextRef | info:pmid/11371554#cont:143 |
|---|---|
| MedLine Reference | 11371554:10142 |
| Sentence | PPARalpha is required and is sufficient for the hypoxia-induced deactivation of M-CPT I gene transcription. |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i29 p27605 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/29/27605 |
| Organism | Mus musculus |
|---|---|
| TextRef | info:pmid/15262994#cont:263 |
| Organ | heart |
| MedLine Reference | 15262994:10262 |
| Sentence | However, we cannot exclude the possibility that Cn-mediated activation of PGC-1/PPARa regulates M-CPT I gene expression in certain contexts. |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i38 p39593 |
| Journal Link | http://www.jbc.org/cgi/content/full/279/38/39593 |
| TextRef | info:pmid/10721894#cont:42 |
|---|---|
| Organ | heart |
| MedLine Reference | 10721894:10041 |
| Sentence | High levels of long-chain fatty acids stimulate their own metabolism by activation of PPARa, which in turn induces fatty acid oxidation by transcriptional activation of both the L- and M-CPTI genes. |
| Journal | Nutrition |
| Journal Reference | v130 i2 p310S |
| Journal Link | http://www.nutrition.org/cgi/content/full/130/2/310S |
| CellLineName | PAZ6 |
|---|---|
| TextRef | info:pmid/11875072#cont:146 |
| MedLine Reference | 11875072:10145 |
| Sentence | The PPARalpha-mediated transcriptional activation of the muscle carnitine palmitoyltransferase I promoter was also enhanced by this signaling pathway ( 32 ) and was associated with phosphorylation of PPARalpha. |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i19 p16750 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/19/16750 |
| TextRef | info:pmid/11577087#cont:98 |
|---|---|
| Organ | heart |
| MedLine Reference | 11577087:10097 |
| Sentence | These results together with the in vitro kinase data suggest that phosphorylation by p38 kinase augments PPARalpha-mediated activation of M-CPT I gene transcription in cardiac myocytes. |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i48 p44495 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/48/44495 |
| CellType | myocyte |
| TextRef | info:pmid/10464303#cont:29 |
|---|---|
| Organ | heart |
| MedLine Reference | 10464303:10028 |
| Sentence | Studies performed in cell culture ( 24 , 25 ) and in vivo ( 26 , 27 ) have demonstrated that basal and fatty acid stimulated expression of the MCAD and muscle carnitine palmitoyltransferase I genes in heart and liver is controlled in part by RXRalpha/PPARalpha heterodimers. |
| Journal | J. Biol. Chem |
| Journal Reference | v274 i36 p25668 |
| Journal Link | http://www.jbc.org/cgi/content/full/274/36/25668 |