| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:1962::unknown |
|---|---|
| References | 5 |
| Connectivity | 2 |
| Effect | unknown |
| TextRef | info:pmid/14500732#cont:107 |
|---|---|
| Organ | liver |
| MedLine Reference | 14500732:10106 |
| Sentence | Increase in hepatic SCP2/SCPx mRNA level indicates ( Fig. 4 B ) that this gene, like AOX , L - PBE , and PTL , is also regulated by PPARalpha. |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i47 p47232 |
| Journal Link | http://www.jbc.org/cgi/content/full/278/47/47232 |
| CellLineName | A3 |
|---|---|
| Organism | Mus musculus |
| TextRef | info:pmid/10844002#cont:240 |
| Organ | liver |
| MedLine Reference | 10844002:10239 |
| Sentence | Our studies also confirm increases in mRNA levels of PPARalpha-regulated genes such as L -PBE, PTL , CYP4A1, and CY4 A3 in livers of wild type mice following fasting. |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i37 p28918 |
| Journal Link | http://www.jbc.org/cgi/content/full/275/37/28918 |
| TextRef | info:pmid/14645497#cont:209 |
|---|---|
| MedLine Reference | 14645497:10208 |
| Sentence | Similarly, when PPARa is bound to its target element on acyl-coenzyme A (CoA) oxidase (AOx) gene, the receptor activity is inhibited by overexpression of SHP, but, conversely, when PPARa binds to its target element on enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase gene promoter, its activity is augmented by overexpression of SHP ( 50 ). |
| Journal | Mol. Endocrin |
| Journal Reference | v18 i2 p312 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/2/312 |
| Organism | Mus musculus |
|---|---|
| TextRef | info:pmid/11551940#cont:122 |
| Organ | liver |
| MedLine Reference | 11551940:10121 |
| Sentence | Human PPARalpha-directed Gene Expression in PPARalpha -/- Mouse Liver-- To investigate whether human PPARalpha is sufficient for the mediation of peroxisome proliferator-induced immediate pleiotropic responses in PPARalpha -/- mouse liver, we evaluated the mRNA levels of several well known PPARalpha-regulated genes such as AOX , L-PBE , peroxisomal 3-ketoacyl-CoA thiolase, CYP4A1, and CYP4A3 by Northern blotting (Fig. 4 A ). |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i45 p42485 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/45/42485 |
| TextRef | info:pmid/15226431#cont:121 |
|---|---|
| MedLine Reference | 15226431:10120 |
| Sentence | Since fatty acid metabolism has been studied to a great extent in peroxisome proliferation, 7 of the 12 proteins, AOX ( 4 , 25 , 44 , 51 ), medium-chain acyl-CoA dehydrogenase ( 7 , 34 ), acyl-CoA thioesterase 1 ( 9 , 47 , 48 ), 3-hydroxy-3-methylglutaryl-CoA synthase 1 ( 45 ), 3-ketoacyl-CoA thiolase A ( 33 , 44 ), acyl-CoA thioester hydrolase ( 2 ), and L -peroxisomal bifunctional enzyme ( 33 , 37 , 44 ), had previously been reported to be regulated in AOX?/? mice or regulated by peroxisome proliferator treatment due to PPARalpha activation. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i14 p6288 |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/14/6288 |