| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:1581::unknown |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | unknown |
| MedLine Reference | 14960721:0 |
|---|---|
| Sentence | In previous work, we showed that the binding of the liver x receptor alpha:peroxisome proliferator-activated receptor alpha (LXRalpha:PPARalpha) heterodimer to the murine Cyp7a1 gene promoter antagonizes the stimulatory effect of their respective ligands. |
| Organ | liver |
|---|---|
| MedLine Reference | 12117567:3 |
| Sentence | PPARalpha and LXRalpha form an atypical heterodimer that binds to two directly adjacent hexameric sequences localized within overlapping PPARalpha and LXRalpha response elements (termed Site I), antagonizing the interaction of PPARalpha:retinoid X receptor alpha (RXRalpha) or RXRalpha:LXRalpha with the Cyp7a1 gene promoter. |
| Tissue | fat |
|---|---|
| MedLine Reference | 10777541:10185 |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i17 p12530 |
| Journal Link | http://www.jbc.org/cgi/content/full/275/17/12530 |