| References | 3 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:6319::positive |
| Organ | liver |
|---|---|
| MedLine Reference | 18079124:7 |
| Sentence | We conclude that intact PPARalpha is required to mediate the response of Scd-1 and Fas gene expression to insulin and that this is normally achieved directly by activation of LXRalpha. |
| Organ | liver |
|---|---|
| MedLine Reference | 15199412:10276 |
| Sentence | SCD1 expression is positively regulated by SREBP1c, C/EBPa, and PPARa ( 56 , 57 ) but negatively regulated by PPAR? ligands ( 58 ). |
| CellType | hepatocyte |
| Journal | J Clin Invest |
| Journal Reference | v113 i12 p1774 |
| Journal Link | http://www.jci.org/cgi/content/full/113/12/1774 |
| Organ | liver |
|---|---|
| MedLine Reference | 12736163:10150 |
| Sentence | PPARalpha also regulates the expression of SCD1, which mainly converts palmitic acid and stearic acid to their monounsaturated forms ( 36 ). |
| Journal | Endocrin. Metabol |
| Journal Reference | v285 i3 pE504 |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/285/3/E504 |