| References | 11 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:10062::positive |
| MedLine Reference | 14960721:4 |
|---|---|
| Sentence | The binding of LXRalpha:PPARalpha to human CYP7A1 Site I was increased in the presence of either LXRalpha or PPARalpha ligands. |
| CellLineName | McArdle RH7777 |
| MedLine Reference | 18498712:2 |
|---|---|
| Sentence | Peroxisome proliferator-activated receptor alpha (PPARalpha) can increase expression of liver X receptor alpha (LXRalpha) in macrophages and thereby promote the expression of ABCA1, which, in turn, mediates cholesterol efflux to apoA1. |
| CellType | macrophage |
| MedLine Reference | 15489539:10131 |
|---|---|
| Sentence | Activation of PPARa can lead to the induction of expression of LXRa, which can then stimulate ABCA1 expression and promote efflux of cholesterol to apoA-I ( 66 ). |
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v45 i12 p2161 |
| Journal Link | http://www.jlr.org/cgi/content/full/45/12/2161 |
| MedLine Reference | 11875109:10053 |
|---|---|
| CellLineName | THP I |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i3 p506 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/3/506 |
| MedLine Reference | 16177188:10182 |
|---|---|
| Journal | Nutrition |
| Journal Reference | v135 i10 p2313 |
| Journal Link | http://jn.nutrition.org/cgi/content/full/135/10/2313 |
| Organ | liver |
|---|---|
| MedLine Reference | 15371561:10325 |
| Journal | Mol. Pharm |
| Journal Reference | v66 i6 p1440 |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/66/6/1440 |
| MedLine Reference | 12730331:10233 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i7 p1240 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/7/1240 |
| Tissue | mesangia |
|---|---|
| MedLine Reference | 12595494:10021 |
| Journal | J. Am. Soc. Nephrology |
| Journal Reference | v14 i3 p593 |
| Journal Link | http://jasn.asnjournals.org/cgi/content/full/14/3/593 |
| Organ | liver |
|---|---|
| MedLine Reference | 14960661:10209 |
| Journal | JPET |
| Journal Reference | v309 i3 p861 |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/309/3/861 |
| MedLine Reference | 16825673:10244 |
|---|---|
| CellType | keratinocyte |
| Journal | Lipid Res |
| Journal Reference | v47 i10 p2248 |
| Journal Link | http://www.jlr.org/cgi/content/full/47/10/2248 |
| MedLine Reference | 11792716:10191 |
|---|---|
| CellType | macrophage |
| Journal | Lipid Res |
| Journal Reference | v43 i1 p2 |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/2 |