| References | 4 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:5106::positive |
| Organ | liver |
|---|---|
| MedLine Reference | 15564327:7 |
| Sentence | Activation of FXR initiated a cascade involving induction of peroxisome proliferator-activated receptor alpha and TRB3 expression that is consistent with stimulation of PEPCK gene expression via interference with a pathway that may involve Akt-dependent phosphorylation of Forkhead/winged helix transcription factor (FOXO1). |
| Organ | liver |
|---|---|
| MedLine Reference | 14722127:10019 |
| Sentence | PEPCK promoter has been extensively studied and shown to be induced by several hormonal stimuli (glucocorticoid, glucagons, and thyroid hormone) and transcriptional factors (cAMP-response element-binding protein, C/EBPa, HNF-3, HNF-4a, and PPARa) ( 1 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i13 p12027 |
| Journal Link | http://www.jbc.org/cgi/content/full/279/13/12027 |
| Organ | liver |
|---|---|
| MedLine Reference | 16804070:10103 |
| Journal | Diabetes |
| Journal Reference | v55 i7 p2015 |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/55/7/2015 |
| MedLine Reference | 11399762:10052 |
|---|---|
| CellType | hepatocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i32 p30561 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/32/30561 |