| References | 2 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:1575::positive |
| MedLine Reference | 10037683:10137 |
|---|---|
| Sentence | In addition to CAR , pregnenolone X receptor, and peroxisome proliferator-activated receptor alpha activate xenochemical-induced transcription of the CYP3A and CYP4A genes, respectively ( 20-23 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v274 i10 p6043 |
| Journal Link | http://www.jbc.org/cgi/content/full/274/10/6043 |
| Organ | liver |
|---|---|
| MedLine Reference | 12391282:10016 |
| Sentence | In particular, the CAR, PXR, and PPARalpha receptors are now known to mediate the effects of myriad xenobiotics on hepatic CYP2B, CYP3A, and CYP4A expression, respectively (Lee et al., 1995 ; Lehmann et al., 1998 ; Wei et al., 2000 ). |
| Journal | Mol. Pharm |
| Journal Reference | v62 i5 p1177 |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/62/5/1177 |