| References | 2 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:6822::positive |
| MedLine Reference | 15635043:10036 |
|---|---|
| Sentence | The evidence also indicates that PPARa transactivates (HUMAN)SULT2A1 gene transcription via a PPRE located in the distal portion of the 5'-flanking region of the (HUMAN)SULT2A1 gene. |
| CellType | hepatocyte |
| Journal | Mol. Pharm |
| Journal Reference | v67 i4 p1257 |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/67/4/1257 |
| Organ | liver |
|---|---|
| MedLine Reference | 16339912:10163 |
| Sentence | Since the PPARa transcription factor was recently demonstrated to regulate human SULT2A1 expression in primary adult human hepatocytes and in HepG2 cells (Fang et al., 2005b ), it is reasonable to expect that endogenous activators of PPARa, such as lipid mediators generated during hepatic biogenesis, may influence the temporal shift in SULT2A1 expression that occurs with progressive liver maturation. |
| CellType | hepatocyte |
| CellLineName | HepG 2 |
| Journal | JPET |
| Journal Reference | v316 i3 p1310 |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/316/3/1310 |