| References | 10 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:7351::positive |
| MedLine Reference | 16782780:8 |
|---|---|
| Sentence | This study shows that PPARalpha activation can upregulate UCP-2 expression, which in turn enhances cyanide-induced necrotic cell death through an increase of mitochondrial dysfunction. |
| Tissue | fat |
|---|---|
| MedLine Reference | 9389729:10371 |
| Sentence | Ailhaud(1997)Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. |
| Journal | J Clin Invest |
| Journal Reference | v100 i11 p2665 |
| Journal Link | http://www.jci.org/cgi/content/full/100/11/2665 |
| MedLine Reference | 12032169:10191 |
|---|---|
| CellLineName | INS-1 cell |
| Journal | Lipid Res |
| Journal Reference | v43 i6 p936 |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/936 |
| Organ | liver |
|---|---|
| Tissue | fat |
| MedLine Reference | 12756242:10044 |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i33 p30525 |
| Journal Link | http://www.jbc.org/cgi/content/full/278/33/30525 |
| Tissue | fat |
|---|---|
| MedLine Reference | 9802886:10511 |
| Journal | J Clin Invest |
| Journal Reference | v102 i9 p1724 |
| Journal Link | http://www.jci.org/cgi/content/full/102/9/1724 |
| Organ | liver |
|---|---|
| MedLine Reference | 15514275:10171 |
| Journal | Nutrition |
| Journal Reference | v134 i11 p3054 |
| Journal Link | http://jn.nutrition.org/cgi/content/full/134/11/3054 |
| Tissue | marrow |
|---|---|
| MedLine Reference | 15961559:10052 |
| Journal | Endocrinology |
| Journal Reference | v146 i9 p3943 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/146/9/3943 |
| Tissue | muscle |
|---|---|
| MedLine Reference | 10529898:10679 |
| Journal | Endocrine Reviews |
| Journal Reference | v20 i5 p649 |
| Journal Link | http://edrv.endojournals.org/cgi/content/full/20/5/649 |
| MedLine Reference | 11278377:10037 |
|---|---|
| CellType | cardiomyocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i14 p10853 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/14/10853 |
| MedLine Reference | 11782473:9 |
|---|---|
| CellType | hepatocyte |