| References | 10 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5465:out-urn:agi-llid:6347::positive |
| Organ | aorta |
|---|---|
| Tissue | endothelial |
| MedLine Reference | 11390455:10205 |
| Sentence | A recent study demonstrated that activation of PPARa with the synthetic ligand WY-14643 stimulates the synthesis of IL-8 and MCP-1 by human aortic endothelial cells ( 22 ). |
| Journal | J. Immunol |
| Journal Reference | v166 i12 p7104 |
| Journal Link | http://www.jimmunol.org/cgi/content/full/166/12/7104 |
| Tissue | endothelial |
|---|---|
| MedLine Reference | 15489539:10140 |
| Sentence | On the other hand, some studies have suggested potential proatherogenic consequences of PPARa activation, such as the ability of PPARa agonists to stimulate the production of MCP-1 in endothelial cells ( 77 ), which would be expected to enhance the recruitment of monocytes into lesions. |
| CellType | monocyte |
| Journal | Lipid Res |
| Journal Reference | v45 i12 p2161 |
| Journal Link | http://www.jlr.org/cgi/content/full/45/12/2161 |
| MedLine Reference | 15814532:10151 |
|---|---|
| Journal | Renal Phys |
| Journal Reference | v289 i2 p469 |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/289/2/F469 |
| Tissue | endothelial |
|---|---|
| MedLine Reference | 11751881:10015 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i9 p7271 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/9/7271 |
| Tissue | endothelial |
|---|---|
| MedLine Reference | 12623780:10148 |
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH1 |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H1 |
| Tissue | vessel wall |
|---|---|
| MedLine Reference | 15001458:10199 |
| Journal | ATVB |
| Journal Reference | v24 i5 p851 |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/5/851 |
| Organ | aorta |
|---|---|
| Tissue | endothelial |
| MedLine Reference | 12006382:10097 |
| Journal | ATVB |
| Journal Reference | v22 i5 p717 |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/22/5/717 |
| Tissue | endothelial |
|---|---|
| MedLine Reference | 16600694:5 |
| Organ | brain |
|---|---|
| Tissue | glia |
| MedLine Reference | 15891579:4 |
| MedLine Reference | 15465833:10294 |
|---|---|
| CellType | monocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i51 p53395 |
| Journal Link | http://www.jbc.org/cgi/content/full/279/51/53395 |