| URN | urn:agi-llid:51 |
|---|---|
| Name | ACOX1 |
| Description | acyl-Coenzyme A oxidase 1, palmitoyl |
| Connectivity | 82 |
| Notes | The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] |
| Swiss-Prot Accession | Q15067 |
|---|---|
| Q7Z3W5 | |
| Q8BYC3 | |
| Q8BW35 | |
| Q8C168 | |
| Q9R0H0 | |
| P07872 |
| Unigene ID | Hs.464137 |
|---|---|
| Mm.356689 | |
| Rn.31796 |
| KEGG ID | hsa:51 |
|---|---|
| mmu:11430 | |
| rno:50681 |
| EC Number | 1.3.3.6 |
|---|
| Swiss-Prot ID | ACOX1_HUMAN |
|---|---|
| ACOX1_RAT | |
| Q8BYC3_MOUSE |
| Cell Localization | Mitochondria |
|---|
| GO ID | 0050660 |
|---|---|
| 0003995 | |
| 0003997 | |
| 0009055 | |
| 0047485 | |
| 0006635 | |
| 0006091 | |
| 0006629 | |
| 0055114 | |
| 0006693 | |
| 0007283 | |
| 0005737 | |
| 0005739 | |
| 0005778 | |
| 0005777 | |
| 0016491 | |
| 0016627 | |
| 0006631 | |
| 0008152 | |
| 0005504 | |
| 0016401 | |
| 0033540 |
| Pathway | New Pathway |
|---|---|
| PPARalpha Pathway |
| IPI ID | IPI00296907 |
|---|---|
| IPI00477729 | |
| IPI00127558 | |
| IPI00404355 | |
| IPI00409360 | |
| IPI00828479 | |
| IPI00211510 | |
| IPI00231941 |
| Ariadne Ontology | Fatty acid oxidation |
|---|
| Mouse chromosome position | 11 E2 |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| FAD binding | |
| fatty acid binding | |
| protein N-terminus binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on the CH-CH group of donors | |
| acyl-CoA dehydrogenase activity | |
| acyl-CoA oxidase activity | |
| palmitoyl-CoA oxidase activity |
| Homologene ID | 38299 |
|---|
| Hugo ID | 119 |
|---|
| GO Cellular Component | cytoplasm |
|---|---|
| mitochondrion | |
| peroxisome | |
| peroxisomal membrane |
| MGI ID | 1330812 |
|---|
| Human chromosome position | 17q24-q25 |
|---|
| GO Biological Process | metabolic process |
|---|---|
| generation of precursor metabolites and energy | |
| fatty acid beta-oxidation | |
| fatty acid beta-oxidation using acyl-CoA oxidase | |
| fatty acid metabolic process | |
| prostaglandin metabolic process | |
| oxidation reduction | |
| lipid metabolic process | |
| spermatogenesis |
| Rat chromosome position | 10q32.3 |
|---|
| Group | Fatty acid oxidation |
|---|---|
| cytoplasm | |
| mitochondrion | |
| peroxisome | |
| peroxisomal membrane | |
| electron carrier activity | |
| FAD binding | |
| fatty acid binding | |
| protein N-terminus binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on the CH-CH group of donors | |
| acyl-CoA dehydrogenase activity | |
| acyl-CoA oxidase activity | |
| palmitoyl-CoA oxidase activity | |
| metabolic process | |
| generation of precursor metabolites and energy | |
| fatty acid beta-oxidation | |
| fatty acid beta-oxidation using acyl-CoA oxidase | |
| fatty acid metabolic process | |
| prostaglandin metabolic process | |
| oxidation reduction | |
| lipid metabolic process | |
| spermatogenesis |
| RGD ID | 619757 |
|---|
| LocusLink ID | 51 |
|---|---|
| 11430 | |
| 50681 |
| Alias | ACOX |
|---|---|
| SCOX | |
| MGC1198 | |
| PALMCOX | |
| acyl-Coenzyme A oxidase 1 | |
| acyl-CoA oxidase, straight-chain | |
| peroxisomal fatty acyl-CoA oxidase | |
| AOX | |
| AI042784 | |
| D130055E20Rik | |
| RP23-42F6.11 | |
| Acyl-CoA oxidase | |
| OTTMUSP00000003995 | |
| RATACOA1 | |
| Acox1 | |
| palmitoyl acyl-Coenzyme A oxidase | |
| Acox I | |
| acyl-CoA oxidase I | |
| acyl-coenzyme A oxidase I | |
| acyl-Coenzyme A oxidase isoform a | |
| PALMCOXs | |
| RATACOA I | |
| acyl-Coenzyme A oxidase isoform b | |
| acyl-coenzyme a oxidase | |
| RIKEN cDNA D130055E20 gene | |
| acyl-CoA oxidase 1 | |
| acyl-Coenzyme A oxidase 1, palmitoyl | |
| Acyl-coenzyme A oxidase 1, peroxisomal | |
| Palmitoyl-CoA oxidase | |
| peroxisomal (palmitoyl-coa oxidase) | |
| acyl-coenzyme A oxidase 1, peroxisomal (Palmitoyl-CoA oxidase) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609751 |
|---|---|
| 264470 |