| URN | urn:agi-llid:6554 |
|---|---|
| Name | SLC10A1 |
| Description | solute carrier family 10 (sodium/bile acid cotransporter family), member 1 |
| Connectivity | 92 |
| Notes | Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2; MIM 601295), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).[supplied by OMIM] |
| Swiss-Prot Accession | Q14973 |
|---|---|
| Q9UK36 | |
| O35940 | |
| O08705 | |
| Q91XS4 | |
| P26435 | |
| Q6LE48 |
| Unigene ID | Hs.952 |
|---|---|
| Mm.341781 | |
| Rn.9913 |
| KEGG ID | hsa:6554 |
|---|---|
| mmu:20493 | |
| rno:24777 |
| Swiss-Prot ID | NTCP_HUMAN |
|---|---|
| NTCP_RAT | |
| B9EGB6_HUMAN | |
| O35940_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0008508 |
|---|---|
| 0031402 | |
| 0015293 | |
| 0015721 | |
| 0006811 | |
| 0015711 | |
| 0006814 | |
| 0005887 | |
| 0005624 | |
| 0005886 | |
| 0006810 | |
| 0016021 | |
| 0016020 | |
| 0022857 |
| Pathway | FXR Targets |
|---|---|
| Toxicology Array | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00001637 |
|---|---|
| IPI00115482 | |
| IPI00460167 | |
| IPI00193374 |
| Ariadne Ontology | Na+ influx co-transport |
|---|---|
| OA transport |
| Mouse chromosome position | 12 37.0 cM |
|---|
| GO Molecular Function | sodium ion binding |
|---|---|
| bile acid:sodium symporter activity | |
| symporter activity |
| Homologene ID | 31126 |
|---|
| Hugo ID | 10905 |
|---|
| GO Cellular Component | membrane |
|---|---|
| membrane fraction | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MGI ID | 97379 |
|---|
| Human chromosome position | 14q24.1 |
|---|
| GO Biological Process | transport |
|---|---|
| ion transport | |
| organic anion transport | |
| sodium ion transport | |
| bile acid and bile salt transport |
| Rat chromosome position | 6q24 |
|---|
| Group | Na+ influx co-transport |
|---|---|
| OA transport | |
| membrane | |
| membrane fraction | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| sodium ion binding | |
| bile acid:sodium symporter activity | |
| symporter activity | |
| transport | |
| ion transport | |
| organic anion transport | |
| sodium ion transport | |
| bile acid and bile salt transport |
| RGD ID | 3681 |
|---|
| LocusLink ID | 6554 |
|---|---|
| 20493 | |
| 24777 |
| Alias | NTCP |
|---|---|
| solute carrier family 10, member 1 | |
| growth-inhibiting protein 29 | |
| sodium/bile acid cotransporter | |
| sodium/taurocholate cotransporter | |
| Na/taurocholate cotransporting polypeptide | |
| bile acid cotransporting polypeptide | |
| sodium-taurocholate cotransporting polypeptide | |
| Ntcp1 | |
| SBACT | |
| sodium-dependent bile acid cotransporter | |
| NA-dependent cholate transporting protein | |
| sodium-dependent taurocholate cotransporting polypeptide | |
| bile acid cotransporting polypeptide 1 | |
| Na(+)/taurocholate transport protein | |
| Na(+)/bile acid cotransporter 1 | |
| Slc10a1 | |
| Sodium/taurocholate cotransporting polypeptide | |
| solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | |
| Slc10a I | |
| Sodium/bile acid cotransporter 1 | |
| NA-dependent cholate transporting protein 1 | |
| solute carrier family 10, member I | |
| NTCP I | |
| sodium-dependent taurocholate cotransporter | |
| sodium-dependent bile acid cotransporter 1 | |
| sodium-taurocholate cotransporting | |
| Na(+)/ taurocholate transport protein | |
| Na(+)/bile acid cotransporter | |
| solute carrier family 10 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 182396 |
|---|