| URN | urn:agi-llid:1571 |
|---|---|
| Name | CYP2E1 |
| Description | cytochrome P450, family 2, subfamily E, polypeptide 1 |
| Connectivity | 271 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq] |
| Swiss-Prot Accession | P05181 |
|---|---|
| Q5VZD5 | |
| Q16868 | |
| Q3YA63 | |
| Q4LBD0 | |
| Q573G9 | |
| Q573H0 | |
| Q59EW1 | |
| Q6LER5 | |
| Q6NWT7 | |
| Q6NWT9 | |
| Q05421 | |
| Q0PGA0 | |
| Q0PGA1 | |
| P05182 | |
| Q71US7 | |
| Q71UV8 |
| Unigene ID | Hs.12907 |
|---|---|
| Mm.21758 | |
| Mm.470181 | |
| Rn.1372 |
| KEGG ID | hsa:1571 |
|---|---|
| mmu:13106 | |
| rno:25086 |
| EC Number | 1.14.14.1 |
|---|
| Swiss-Prot ID | CP2E1_HUMAN |
|---|---|
| CP2E1_MOUSE | |
| CP2E1_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0070330 |
|---|---|
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0019825 | |
| 0055114 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0016712 | |
| 0010181 | |
| 0006805 | |
| 0000139 | |
| 0031227 | |
| 0005739 |
| Pathway | Toxicology Array |
|---|---|
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00007282 |
|---|---|
| IPI00816414 | |
| IPI00816043 | |
| IPI00555724 | |
| IPI00110556 | |
| IPI00785311 | |
| IPI00785323 | |
| IPI00324912 |
| Ariadne Ontology | Leukotriene synthesis |
|---|
| Mouse chromosome position | 7 68.4 cM |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| oxygen binding | |
| FMN binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity |
| Homologene ID | 68089 |
|---|
| Hugo ID | 2631 |
|---|
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| intrinsic to endoplasmic reticulum membrane | |
| mitochondrion | |
| endoplasmic reticulum |
| MGI ID | 88607 |
|---|
| Human chromosome position | 10q24.3-qter |
|---|
| GO Biological Process | xenobiotic metabolic process |
|---|---|
| oxidation reduction |
| Group | Leukotriene synthesis |
|---|---|
| membrane | |
| microsome | |
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| intrinsic to endoplasmic reticulum membrane | |
| mitochondrion | |
| endoplasmic reticulum | |
| electron carrier activity | |
| oxygen binding | |
| FMN binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| xenobiotic metabolic process | |
| oxidation reduction |
| RGD ID | 2475 |
|---|
| LocusLink ID | 1571 |
|---|---|
| 13106 | |
| 25086 |
| Alias | CPE1 |
|---|---|
| CYP2E | |
| P450-J | |
| P450C2E | |
| cytochrome P450, family 2, subfamily E, polypeptide 1 | |
| OTTHUMP00000020813 | |
| OTTHUMP00000046571 | |
| cytochrome P450 2E1 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 | |
| cytochrome P450, 2e1, ethanol inducible | |
| cytochrome P450, subfamily 2E, polypeptide 1 | |
| cytochrome P450 subfamily 2e1 (ethanol-inducible) | |
| Cyp2e1 | |
| cytochrome P450, family 2, subfamily E, polypeptide | |
| cytochrome P450, subfamily IIE, polypeptide 1 | |
| cytochrome P450, subfamily IIE, polypeptide I | |
| CYPIIE1 | |
| cytochrome P450, subfamily IIE (ethanol-inducible) | |
| cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide I | |
| CYPIIE I | |
| Cytochrome P450 2E I | |
| Cyp2e I | |
| Cytochrome P450, subfamily 2e1 (ethanol-inducible) | |
| CPE I | |
| P450-Js |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 124040 |
|---|