| URN | urn:agi-llid:948 |
|---|---|
| Name | CD36 |
| Description | CD36 molecule (thrombospondin receptor) |
| Connectivity | 440 |
| Notes | The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |
| Swiss-Prot Accession | A4D1B1 |
|---|---|
| P16671 | |
| Q13965 | |
| Q9BQA7 | |
| Q9BZM7 | |
| Q9BZM9 | |
| Q9BZN0 | |
| Q9BZN1 | |
| Q9BZN2 | |
| Q9BZN6 | |
| Q08857 | |
| Q3TA14 | |
| Q3U6Y9 | |
| Q3UAI3 | |
| Q3UC79 | |
| Q8C6Z4 | |
| Q9CT95 | |
| Q6IMX5 | |
| O35754 | |
| Q07969 | |
| Q794J1 | |
| Q5BKE5 |
| Unigene ID | Hs.120949 |
|---|---|
| Mm.18628 | |
| Mm.406799 | |
| Rn.102418 | |
| Rn.205840 | |
| Hs.633085 |
| KEGG ID | hsa:948 |
|---|---|
| mmu:12491 | |
| rno:29184 | |
| rno:499985 | |
| rno:685953 |
| Swiss-Prot ID | CD36_HUMAN |
|---|---|
| CD36_MOUSE | |
| A4D1B1_HUMAN | |
| Q3UAI3_MOUSE | |
| Q5BKE5_RAT | |
| Q6IMX5_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0008035 |
|---|---|
| 0008289 | |
| 0005041 | |
| 0070053 | |
| 0050431 | |
| 0043277 | |
| 0007596 | |
| 0019934 | |
| 0007155 | |
| 0030301 | |
| 0006629 | |
| 0019915 | |
| 0042159 | |
| 0034381 | |
| 0042953 | |
| 0007263 | |
| 0015911 | |
| 0001954 | |
| 0010744 | |
| 0006810 | |
| 0005794 | |
| 0009986 | |
| 0005887 | |
| 0005624 | |
| 0005886 | |
| 0031092 | |
| 0005515 | |
| 0004872 | |
| 0016021 | |
| 0016020 | |
| 0005504 | |
| 0006631 | |
| 0019395 | |
| 0015908 | |
| 0001676 | |
| 0015909 | |
| 0006641 | |
| 0045177 | |
| 0005901 | |
| 0005622 | |
| 0005792 | |
| 0005739 | |
| 0042383 |
| Pathway | Cardiovascular Disease (Large) |
|---|---|
| CVD and receptors (all) | |
| CVD and receptors (all) + Ligands | |
| PPARG Brief | |
| Figure 3 CAR 2009 | |
| PPARG Targets | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00418495 |
|---|---|
| IPI00745287 | |
| IPI00331214 | |
| IPI00231197 | |
| IPI00556921 | |
| IPI00763638 | |
| IPI00781829 | |
| IPI00765613 | |
| IPI00766856 |
| Ariadne Ontology | Receptors |
|---|
| Mouse chromosome position | 5 2.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| lipid binding | |
| fatty acid binding | |
| transforming growth factor beta binding | |
| high-density lipoprotein binding | |
| low-density lipoprotein receptor activity | |
| receptor activity | |
| thrombospondin receptor activity |
| Hugo ID | 1663 |
|---|
| GO Cellular Component | intracellular |
|---|---|
| cell surface | |
| membrane | |
| apical part of cell | |
| membrane fraction | |
| microsome | |
| platelet alpha granule membrane | |
| mitochondrion | |
| Golgi apparatus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| caveola | |
| sarcolemma |
| MGI ID | 107899 |
|---|
| Human chromosome position | 7q11.2 |
|---|
| GO Biological Process | cell adhesion |
|---|---|
| positive regulation of cell-matrix adhesion | |
| positive regulation of foam cell differentiation | |
| nitric oxide mediated signal transduction | |
| cGMP-mediated signaling | |
| blood coagulation | |
| lipoprotein particle clearance | |
| apoptotic cell clearance | |
| fatty acid metabolic process | |
| long-chain fatty acid metabolic process | |
| fatty acid oxidation | |
| triglyceride metabolic process | |
| lipoprotein catabolic process | |
| transport | |
| lipoprotein transport | |
| fatty acid transport | |
| long-chain fatty acid transport | |
| plasma membrane long-chain fatty acid transport | |
| cholesterol transport | |
| lipid storage | |
| lipid metabolic process |
| Rat chromosome position | 4q11 |
|---|
| Group | Receptors |
|---|---|
| intracellular | |
| cell surface | |
| membrane | |
| apical part of cell | |
| membrane fraction | |
| microsome | |
| platelet alpha granule membrane | |
| mitochondrion | |
| Golgi apparatus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| caveola | |
| sarcolemma | |
| protein binding | |
| lipid binding | |
| fatty acid binding | |
| transforming growth factor beta binding | |
| high-density lipoprotein binding | |
| low-density lipoprotein receptor activity | |
| receptor activity | |
| thrombospondin receptor activity | |
| cell adhesion | |
| positive regulation of cell-matrix adhesion | |
| positive regulation of foam cell differentiation | |
| nitric oxide mediated signal transduction | |
| cGMP-mediated signaling | |
| blood coagulation | |
| lipoprotein particle clearance | |
| apoptotic cell clearance | |
| fatty acid metabolic process | |
| long-chain fatty acid metabolic process | |
| fatty acid oxidation | |
| triglyceride metabolic process | |
| lipoprotein catabolic process | |
| transport | |
| lipoprotein transport | |
| fatty acid transport | |
| long-chain fatty acid transport | |
| plasma membrane long-chain fatty acid transport | |
| cholesterol transport | |
| lipid storage | |
| lipid metabolic process |
| RGD ID | 2301 |
|---|---|
| 1565355 | |
| 1587822 |
| LocusLink ID | 948 |
|---|---|
| 12491 | |
| 29184 | |
| 499985 | |
| 685953 |
| Alias | FAT |
|---|---|
| GP4 | |
| GP3B | |
| GPIV | |
| CHDS7 | |
| PASIV | |
| SCARB3 | |
| CD36 antigen | |
| PAS-4 protein | |
| glycoprotein IIIb | |
| cluster determinant 36 | |
| fatty acid translocase | |
| platelet glycoprotein IV | |
| scavenger receptor class B, member 3 | |
| leukocyte differentiation antigen CD36 | |
| CD36 antigen (collagen type I receptor, thrombospondin receptor) | |
| MGC91634 | |
| MGC108510 | |
| collagen type I receptor thrombospondin receptor | |
| Cd36 antigen-like | |
| similar to CD36 antigen | |
| thrombospondin receptor | |
| thrombospondin receptors | |
| glycoprotein III b | |
| FAT/CD36 | |
| PAS-IV | |
| collagen type 1 receptor | |
| PAS-4 | |
| scavenger receptor class B, member III | |
| CD36 | |
| GPIIIB | |
| CD36 molecule | |
| PAS IV | |
| LOC296786 | |
| LOC362310 | |
| LOC683013 | |
| LOC685953 | |
| RGD1565355 | |
| collagen type I receptor | |
| platelet collagen receptor | |
| CD36 antigen (collagen type I receptor thrombospondin receptor) | |
| hypothetical protein LOC499985 | |
| CD36 antigen (collagen type I) | |
| collagen type 1 | |
| SCARB3s | |
| similar to fatty acid transport protein | |
| cd36 molecule (thrombospondin receptor) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 173510 |
|---|---|
| 610938 | |
| 248310 | |
| 611162 | |
| 608404 |