| URN | urn:agi-llid:1575 |
|---|---|
| Name | CYP3A4 |
| Description | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| Connectivity | 323 |
| Notes | This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. |
| Swiss-Prot Accession | P08684 |
|---|---|
| Q6GRK0 | |
| Q7Z448 | |
| Q86SK2 | |
| Q86SK3 | |
| Q9BZM0 | |
| Q3UEN8 | |
| Q64459 | |
| Q52L54 | |
| Q2KHL4 | |
| Q64481 | |
| Q9JMA7 | |
| Q9EQW4 | |
| Q06884 | |
| P04800 | |
| Q64590 | |
| Q6LEQ2 | |
| P05183 |
| Unigene ID | Hs.654391 |
|---|---|
| Mm.332844 | |
| Mm.378905 | |
| Mm.379071 | |
| Mm.425301 | |
| Rn.91120 |
| KEGG ID | hsa:1576 |
|---|---|
| mmu:13112 | |
| mmu:13114 | |
| mmu:53973 | |
| rno:25642 | |
| rno:266682 | |
| mmu:337924 |
| EC Number | 1.14.14.1 |
|---|---|
| 1.14.13.67 | |
| 1.14.13.97 |
| Swiss-Prot ID | CP3A4_HUMAN |
|---|---|
| CP3AB_MOUSE | |
| Q6GRK0_HUMAN | |
| Q06884_RAT | |
| Q3UEN8_MOUSE | |
| Q9EQW4_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0046872 | |
| 0016712 | |
| 0019825 | |
| 0050591 | |
| 0033780 | |
| 0006629 | |
| 0055114 | |
| 0009986 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005792 | |
| 0070330 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0032451 | |
| 0050649 | |
| 0007568 | |
| 0046686 | |
| 0042493 | |
| 0051384 | |
| 0010038 | |
| 0007584 | |
| 0006805 | |
| 0005624 | |
| 0050381 | |
| 0005615 |
| Pathway | Figure 3 CAR 2009 |
|---|---|
| FXR Targets | |
| Toxicology Array | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00465138 |
|---|---|
| IPI00479050 | |
| IPI00134504 | |
| IPI00125340 | |
| IPI00111634 | |
| IPI00199589 | |
| IPI00324932 |
| Ariadne Ontology | Xenobiotic clearance |
|---|
| Mouse chromosome position | 5 85.0 cM |
|---|---|
| 5 G2 |
| GO Molecular Function | molecular_function |
|---|---|
| electron carrier activity | |
| oxygen binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| demethylase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| quinine 3-monooxygenase activity | |
| aromatase activity | |
| testosterone 6-beta-hydroxylase activity |
| Hugo ID | 2637 |
|---|
| GO Cellular Component | cellular_component |
|---|---|
| cell surface | |
| membrane | |
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| MGI ID | 88609 |
|---|---|
| 106099 | |
| 1858451 | |
| 2449818 | |
| 3714859 |
| Human chromosome position | 7q21.1 |
|---|
| GO Biological Process | biological_process |
|---|---|
| aging | |
| oxidation reduction | |
| lipid metabolic process | |
| response to drug | |
| response to nutrient | |
| response to glucocorticoid stimulus | |
| response to metal ion | |
| response to cadmium ion |
| Rat chromosome position | 12p11 |
|---|
| Group | Xenobiotic clearance |
|---|---|
| cellular_component | |
| cell surface | |
| membrane | |
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane | |
| molecular_function | |
| electron carrier activity | |
| oxygen binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| demethylase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| quinine 3-monooxygenase activity | |
| aromatase activity | |
| testosterone 6-beta-hydroxylase activity | |
| biological_process | |
| aging | |
| oxidation reduction | |
| lipid metabolic process | |
| response to drug | |
| response to nutrient | |
| response to glucocorticoid stimulus | |
| response to metal ion | |
| response to cadmium ion |
| RGD ID | 628626 |
|---|---|
| 708379 |
| LocusLink ID | 1575 |
|---|---|
| 1576 | |
| 13112 | |
| 13114 | |
| 53973 | |
| 337924 | |
| 100041375 | |
| 25642 | |
| 266682 |
| Alias | HLP |
|---|---|
| CP33 | |
| CP34 | |
| CYP3A | |
| NF-25 | |
| CYP3A3 | |
| P450C3 | |
| P450PCN1 | |
| MGC126680 | |
| cytochrome P450, family 3, subfamily A, polypeptide 4 | |
| nifedipine oxidase | |
| P450-III, steroid inducible | |
| glucocorticoid-inducible P450 | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 | |
| Pcn | |
| IIIAm1 | |
| AI256190 | |
| cytochrome P450, family 3, subfamily a, polypeptide 11 | |
| steroid inducible | |
| OTTMUSP00000031951 | |
| cytochrome P450, steroid inducible 3a11 | |
| MGC130513 | |
| cytochrome P450, family 3, subfamily a, polypeptide 16 | |
| OTTMUSP00000030399 | |
| cytochrome P450, 3a16 | |
| Cyp3a41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 41A | |
| cytochrome P450, steroid inducible 3a41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 44 | |
| OTTMUSP00000030400 | |
| cytochrome P450, 3a44 | |
| cytochrome P450, family 3, subfamily a, polypeptide 41B | |
| CYP | |
| RL33 | |
| cDEX | |
| Cyp3a1 | |
| CYP3A23 | |
| MGC108757 | |
| cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 | |
| P450 IIIA | |
| cytochrome P450/6 beta B | |
| cytochrome P-450PCN (PNCN inducible) | |
| cytochrome P450, subfamily 3A, polypeptide 3 | |
| Cytochrome P450, subfamily IIIA, polypeptide 3 | |
| cytochrome P450, family 3, subfamily a, polypeptide 1 | |
| Cyp3a11 | |
| MGC108545 | |
| cytochrome P450, family 3, subfamily a, polypeptide 2 | |
| testosterone 6-beta-hydroxylase | |
| CYPSA4 | |
| Cytochrome P450 3A3 | |
| Cytochrome P450 3A4 | |
| cytochrome P450, family 3, subfamily a, polypeptide 13 | |
| olfactory cytochrome P450olf3 | |
| 8430412F05 | |
| E330004N01 | |
| RIKEN cDNA C230004D03 gene | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide IV | |
| Cytochrome P450 3A21 | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide III | |
| Cytochrome P450, subfamily IIIA, polypeptide III | |
| Cyp3a13 | |
| C230004D03Rik | |
| mKIAA3002 | |
| CYP3A4 | |
| cytochrome P450, subfamily IIIA, polypeptide IV | |
| P450PCN I | |
| cytochrome P450, subfamily IIIA, polypeptide 4 | |
| IIIAm2 | |
| IIIAm I | |
| Cyp3a44 | |
| RL(33) | |
| Cyp3a23/3a1 | |
| Cyp3a41a | |
| Cyp3a41b | |
| CYPIIIA3 | |
| CYPIIIA4 | |
| FLJ11220 | |
| mgc93139 | |
| P450olf3 | |
| IIIAm2s | |
| IIIAm1s | |
| IIIAm Is | |
| Cyp3a16 | |
| CYP3A9 | |
| hypothetical protein 8430412F05 | |
| hypothetical protein FLJ11220 | |
| Cytochrome P450 3A21 (CYPIIIA21) (P450 CM3A-10) | |
| cytochrome P450 3A9 | |
| CYP3A2 | |
| RL 33 | |
| RL-33 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 124010 |
|---|