Protein ABCB4

URN	urn:agi-llid:5244
Name	ABCB4
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 4
Connectivity	53
Notes	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

EC Number	3.6.3.44

Cell Localization	Plasma membrane

Ariadne Ontology	Xenobiotic clearance
	Lipid transport

Mouse chromosome position	5 1.0 cM

GO Molecular Function	protein binding
	nucleotide binding
	ATP binding
	hydrolase activity
	ATPase activity, coupled to transmembrane movement of substances
	xenobiotic-transporting ATPase activity
	nucleoside-triphosphatase activity
	ATPase activity

Homologene ID	113698
	56421

Hugo ID	45

MGI ID	97569

Human chromosome position	7q21.1

GO Biological Process	transport
	lipid metabolic process
	response to drug
	response to glucocorticoid stimulus

Rat chromosome position	4q11-q12

Group	Xenobiotic clearance
	Lipid transport
	membrane
	apical plasma membrane
	membrane fraction
	Golgi membrane
	integral to membrane
	integral to plasma membrane
	intercellular canaliculus
	protein binding
	nucleotide binding
	ATP binding
	hydrolase activity
	ATPase activity, coupled to transmembrane movement of substances
	xenobiotic-transporting ATPase activity
	nucleoside-triphosphatase activity
	ATPase activity
	transport
	lipid metabolic process
	response to drug
	response to glucocorticoid stimulus

RGD ID	620248

Alias	GBD1
	MDR2
	MDR3
	PGY3
	ABC21
	MDR2/3
	PFIC-3
	ATP-binding cassette, subfamily B, member 4
	OTTHUMP00000025014
	multiple drug resistance 3
	multidrug resistance protein 3
	P glycoprotein 3/multiple drug resistance 3
	P-glycoprotein-3/multiple drug resistance-3
	Pgy2
	Pgy-2
	mdr-2
	P glycoprotein 2
	P-glycoprotein 3/ multidrug resistance 2
	ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2
	ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
	ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)
	multi-drug resistance 3
	multi-drug resistance III
	wdr42a
	Pet2
	P-glycoprotein 3/ multidrug resistance II
	ATP-binding cassette, sub-family B (MDR/TAP), member IV
	P-glycoprotein 3
	Abcb4
	ATP-binding cassette, sub-family B (MDR/TAP), member 4
	EST AA792214
	Multidrug resistance protein 2 (P-glycoprotein 2)
	PC231
	ATP-binding cassette, subfamily B, member IV
	ATP-binding cassette, subfamily B, member 4 isoform A
	ATP-binding cassette, subfamily B, member 4 isoform B
	ATP-binding cassette, subfamily B, member 4 isoform C
	D1Ucla4
	plasmacytoma expressed transcript II
	P glycoprotein II
	P-glycoprotein III
	Multidrug resistance protein III
	multiple drug resistance III
	PFIC III
	plasmacytoma expressed transcript 2
	H(326)
	AA408877
	AA792214
	AU018973
	MGC38511
	C76055
	MDR2/3s
	C76055s
	expressed sequence C76055
	expressed sequence AA408877
	expressed sequence AU018973
	H-326
	H326
	H 326