| URN | urn:agi-llid:335 |
|---|---|
| Name | APOA1 |
| Description | apolipoprotein A-I |
| Connectivity | 517 |
| Notes | This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. |
| Swiss-Prot Accession | P02647 |
|---|---|
| Q6LEJ8 | |
| Q8TDB0 | |
| Q9Y355 | |
| Q8BPD5 | |
| O08855 | |
| O09042 | |
| Q00623 | |
| Q3V2G1 | |
| Q58EV2 |
| Unigene ID | Hs.633003 |
|---|---|
| Mm.26743 |
| KEGG ID | hsa:335 |
|---|---|
| mmu:11806 |
| Swiss-Prot ID | APOA1_HUMAN |
|---|---|
| Q8BPD5_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0034191 |
|---|---|
| 0001540 | |
| 0015485 | |
| 0017127 | |
| 0019899 | |
| 0042802 | |
| 0060228 | |
| 0005543 | |
| 0032488 | |
| 0007186 | |
| 0033344 | |
| 0042632 | |
| 0008203 | |
| 0034380 | |
| 0006629 | |
| 0006869 | |
| 0042157 | |
| 0002740 | |
| 0050713 | |
| 0006656 | |
| 0033700 | |
| 0010873 | |
| 0051345 | |
| 0050821 | |
| 0043691 | |
| 0008202 | |
| 0031410 | |
| 0030139 | |
| 0005788 | |
| 0005576 | |
| 0034364 | |
| 0008035 | |
| 0008289 | |
| 0005319 | |
| 0008034 | |
| 0005515 | |
| 0030325 | |
| 0031103 | |
| 0043534 | |
| 0006695 | |
| 0030301 | |
| 0001935 | |
| 0008211 | |
| 0019915 | |
| 0042158 | |
| 0051346 | |
| 0006644 | |
| 0051347 | |
| 0008104 | |
| 0030300 | |
| 0001932 | |
| 0006810 | |
| 0005615 |
| Pathway | HepG2 Extracts |
|---|---|
| Figure 3 CAR 2009 | |
| PPARG Targets | |
| FXR Targets | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00021841 |
|---|---|
| IPI00853525 | |
| IPI00121209 | |
| IPI00877236 |
| Ariadne Ontology | Lipid transport |
|---|
| Mouse chromosome position | 9 27.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| lipid binding | |
| phospholipid binding | |
| cholesterol binding | |
| beta-amyloid binding | |
| lipoprotein binding | |
| enzyme binding | |
| identical protein binding | |
| high-density lipoprotein binding | |
| apolipoprotein A-I receptor binding | |
| phosphatidylcholine-sterol O-acyltransferase activator activity | |
| lipid transporter activity | |
| cholesterol transporter activity |
| Homologene ID | 47900 |
|---|
| Hugo ID | 600 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| cytoplasmic vesicle | |
| endocytic vesicle | |
| endoplasmic reticulum lumen | |
| extracellular space | |
| high-density lipoprotein particle |
| MGI ID | 88049 |
|---|
| Human chromosome position | 11q23-q24 |
|---|
| GO Biological Process | high-density lipoprotein particle assembly |
|---|---|
| negative regulation of cytokine secretion during immune response | |
| negative regulation of interleukin-1 beta secretion | |
| positive regulation of cholesterol esterification | |
| regulation of protein amino acid phosphorylation | |
| G-protein coupled receptor protein signaling pathway | |
| Cdc42 protein signal transduction | |
| regulation of intestinal cholesterol absorption | |
| protein stabilization | |
| cholesterol homeostasis | |
| glucocorticoid metabolic process | |
| negative regulation of hydrolase activity | |
| positive regulation of transferase activity | |
| positive regulation of hydrolase activity | |
| blood vessel endothelial cell migration | |
| endothelial cell proliferation | |
| axon regeneration | |
| cholesterol metabolic process | |
| cholesterol biosynthetic process | |
| steroid metabolic process | |
| lipoprotein biosynthetic process | |
| phosphatidylcholine biosynthetic process | |
| phospholipid metabolic process | |
| lipoprotein metabolic process | |
| adrenal gland development | |
| transport | |
| lipid transport | |
| phospholipid efflux | |
| cholesterol transport | |
| cholesterol efflux | |
| reverse cholesterol transport | |
| protein localization | |
| lipid storage | |
| lipid metabolic process |
| Group | Lipid transport |
|---|---|
| extracellular region | |
| cytoplasmic vesicle | |
| endocytic vesicle | |
| endoplasmic reticulum lumen | |
| extracellular space | |
| high-density lipoprotein particle | |
| protein binding | |
| lipid binding | |
| phospholipid binding | |
| cholesterol binding | |
| beta-amyloid binding | |
| lipoprotein binding | |
| enzyme binding | |
| identical protein binding | |
| high-density lipoprotein binding | |
| apolipoprotein A-I receptor binding | |
| phosphatidylcholine-sterol O-acyltransferase activator activity | |
| lipid transporter activity | |
| cholesterol transporter activity | |
| high-density lipoprotein particle assembly | |
| negative regulation of cytokine secretion during immune response | |
| negative regulation of interleukin-1 beta secretion | |
| positive regulation of cholesterol esterification | |
| regulation of protein amino acid phosphorylation | |
| G-protein coupled receptor protein signaling pathway | |
| Cdc42 protein signal transduction | |
| regulation of intestinal cholesterol absorption | |
| protein stabilization | |
| cholesterol homeostasis | |
| glucocorticoid metabolic process | |
| negative regulation of hydrolase activity | |
| positive regulation of transferase activity | |
| positive regulation of hydrolase activity | |
| blood vessel endothelial cell migration | |
| endothelial cell proliferation | |
| axon regeneration | |
| cholesterol metabolic process | |
| cholesterol biosynthetic process | |
| steroid metabolic process | |
| lipoprotein biosynthetic process | |
| phosphatidylcholine biosynthetic process | |
| phospholipid metabolic process | |
| lipoprotein metabolic process | |
| adrenal gland development | |
| transport | |
| lipid transport | |
| phospholipid efflux | |
| cholesterol transport | |
| cholesterol efflux | |
| reverse cholesterol transport | |
| protein localization | |
| lipid storage | |
| lipid metabolic process |
| LocusLink ID | 335 |
|---|---|
| 11806 |
| Alias | MGC117399 |
|---|---|
| apolipoprotein A-I | |
| OTTHUMP00000069346 | |
| OTTHUMP00000069347 | |
| OTTHUMP00000069348 | |
| Sep2 | |
| Alp-1 | |
| Ltw-1 | |
| Sep-1 | |
| Sep-2 | |
| Apoa-1 | |
| Brp-14 | |
| Lvtw-1 | |
| MGC102525 | |
| apolipoprotein A-1 | |
| Apo-A1 | |
| Apo A-I | |
| APOA1 | |
| Apo-AI | |
| preproapolipoprotein | |
| APOA I | |
| Ltw I | |
| Lvtw I | |
| ApoAI | |
| apolipoprotein AI | |
| preproapolipoprotein a-i | |
| apolipoprotein A1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 107680 |
|---|---|
| 105200 | |
| 604091 |