| URN | urn:agi-llid:6517 |
|---|---|
| Name | SLC2A4 |
| Description | solute carrier family 2 (facilitated glucose transporter), member 4 |
| Connectivity | 594 |
| Notes | This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). |
| Swiss-Prot Accession | P14672 |
|---|---|
| Q3TPK6 | |
| P14142 | |
| P19357 |
| Unigene ID | Hs.380691 |
|---|---|
| Mm.10661 | |
| Rn.1314 |
| KEGG ID | hsa:6517 |
|---|---|
| mmu:20528 | |
| rno:25139 |
| Swiss-Prot ID | GTR4_HUMAN |
|---|---|
| GTR4_RAT | |
| Q3TPK6_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005355 |
|---|---|
| 0005515 | |
| 0022891 | |
| 0005351 | |
| 0005215 | |
| 0005975 | |
| 0008643 | |
| 0042593 | |
| 0046323 | |
| 0055085 | |
| 0005737 | |
| 0005768 | |
| 0009897 | |
| 0000299 | |
| 0005887 | |
| 0005792 | |
| 0048471 | |
| 0005886 | |
| 0030140 | |
| 0012506 | |
| 0005360 | |
| 0050873 | |
| 0015758 | |
| 0006810 | |
| 0030659 | |
| 0016021 | |
| 0016020 | |
| 0055056 | |
| 0005905 | |
| 0012505 | |
| 0032593 | |
| 0005624 | |
| 0005771 | |
| 0042383 | |
| 0005625 | |
| 0031982 |
| Pathway | PPARG Brief |
|---|---|
| Figure 3 CAR 2009 | |
| PPARG Targets | |
| FXR Targets | |
| Toxicology Array | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00027281 |
|---|---|
| IPI00795418 | |
| IPI00762242 | |
| IPI00263726 | |
| IPI00194348 | |
| IPI00778364 |
| Ariadne Ontology | Glucose import |
|---|
| Mouse chromosome position | 11 40.0 cM |
|---|
| GO Molecular Function | transporter activity |
|---|---|
| protein binding | |
| substrate-specific transmembrane transporter activity | |
| sugar:hydrogen symporter activity | |
| glucose transmembrane transporter activity | |
| D-glucose transmembrane transporter activity | |
| insulin-responsive hydrogen:glucose symporter activity |
| Homologene ID | 74381 |
|---|
| Hugo ID | 11009 |
|---|
| GO Cellular Component | endomembrane system |
|---|---|
| membrane | |
| soluble fraction | |
| membrane fraction | |
| integral to membrane of membrane fraction | |
| microsome | |
| external side of plasma membrane | |
| vesicle membrane | |
| cytoplasmic vesicle membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endosome | |
| trans-Golgi network transport vesicle | |
| insulin-responsive compartment | |
| multivesicular body | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| coated pit | |
| sarcolemma | |
| vesicle |
| MGI ID | 95758 |
|---|
| Human chromosome position | 17p13 |
|---|
| GO Biological Process | glucose homeostasis |
|---|---|
| transmembrane transport | |
| brown fat cell differentiation | |
| transport | |
| carbohydrate transport | |
| glucose transport | |
| glucose import | |
| carbohydrate metabolic process |
| Rat chromosome position | 10q24 |
|---|
| Group | Glucose import |
|---|---|
| endomembrane system | |
| membrane | |
| soluble fraction | |
| membrane fraction | |
| integral to membrane of membrane fraction | |
| microsome | |
| external side of plasma membrane | |
| vesicle membrane | |
| cytoplasmic vesicle membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| endosome | |
| trans-Golgi network transport vesicle | |
| insulin-responsive compartment | |
| multivesicular body | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| coated pit | |
| sarcolemma | |
| vesicle | |
| transporter activity | |
| protein binding | |
| substrate-specific transmembrane transporter activity | |
| sugar:hydrogen symporter activity | |
| glucose transmembrane transporter activity | |
| D-glucose transmembrane transporter activity | |
| insulin-responsive hydrogen:glucose symporter activity | |
| glucose homeostasis | |
| transmembrane transport | |
| brown fat cell differentiation | |
| transport | |
| carbohydrate transport | |
| glucose transport | |
| glucose import | |
| carbohydrate metabolic process |
| RGD ID | 2711 |
|---|
| LocusLink ID | 6517 |
|---|---|
| 20528 | |
| 25139 |
| Alias | GLUT4 |
|---|---|
| glucose transporter 4 | |
| insulin-responsive glucose transporter type 4 | |
| Glut-4 | |
| solute carrier family 2 (facilitated glucose transporter), member 4 | |
| OTTMUSP00000006275 | |
| MGC93607 | |
| solute carrier family 2 , member 4 | |
| solute carrier family 2 member 4 | |
| Glucose transporter 4 insuline-responsive | |
| Glucose transporter 4, insuline-responsive | |
| SLC2A4 | |
| facilitated glucose transporter 4 | |
| facilitated glucose transporter IV | |
| solute carrier family 2 (facilitated glucose transporter), member IV | |
| solute carrier family 2 , member IV | |
| Glucose transporter type 4, insulin-responsive |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138190 |
|---|---|
| 125853 |