| URN | urn:agi-llid:7352 |
|---|---|
| Name | UCP3 |
| Description | uncoupling protein 3 (mitochondrial, proton carrier) |
| Connectivity | 163 |
| Notes | Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). Chromosomal order is 5'-UCP3-UCP2-3'. Two splice variants have been found for this gene. |
| Swiss-Prot Accession | P55916 |
|---|---|
| B2RTM2 | |
| P56501 | |
| P56499 |
| Unigene ID | Hs.101337 |
|---|---|
| Hs.621879 | |
| Mm.6254 | |
| Rn.9902 |
| KEGG ID | hsa:7352 |
|---|---|
| mmu:22229 | |
| rno:25708 |
| Swiss-Prot ID | UCP3_HUMAN |
|---|---|
| UCP3_MOUSE | |
| UCP3_RAT | |
| B2RTM2_MOUSE |
| Cell Localization | Mitochondria |
|---|
| GO ID | 0005488 |
|---|---|
| 0017077 | |
| 0005215 | |
| 0006631 | |
| 0006629 | |
| 0006839 | |
| 0015992 | |
| 0007585 | |
| 0001666 | |
| 0000303 | |
| 0006810 | |
| 0016021 | |
| 0016020 | |
| 0005743 | |
| 0005739 | |
| 0015078 | |
| 0006091 | |
| 0005624 |
| Pathway | PPARG Brief |
|---|---|
| Figure 3 CAR 2009 | |
| PPARbeta BCL6 Targets | |
| PPARG Targets | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00026815 |
|---|---|
| IPI00221047 | |
| IPI00221048 | |
| IPI00114153 | |
| IPI00192697 |
| Ariadne Ontology | Respiratory chain |
|---|
| Mouse chromosome position | 7 50.0 cM |
|---|
| GO Molecular Function | binding |
|---|---|
| transporter activity | |
| hydrogen ion transmembrane transporter activity | |
| oxidative phosphorylation uncoupler activity |
| Homologene ID | 2517 |
|---|
| Hugo ID | 12519 |
|---|
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane |
| MGI ID | 1099787 |
|---|
| Human chromosome position | 11q13 |
|---|
| GO Biological Process | mitochondrial transport |
|---|---|
| fatty acid metabolic process | |
| transport | |
| proton transport | |
| lipid metabolic process | |
| respiratory gaseous exchange | |
| response to superoxide | |
| response to hypoxia |
| Rat chromosome position | 1q32 |
|---|
| Group | Respiratory chain |
|---|---|
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane | |
| binding | |
| transporter activity | |
| hydrogen ion transmembrane transporter activity | |
| oxidative phosphorylation uncoupler activity | |
| mitochondrial transport | |
| fatty acid metabolic process | |
| transport | |
| proton transport | |
| lipid metabolic process | |
| respiratory gaseous exchange | |
| response to superoxide | |
| response to hypoxia |
| RGD ID | 3933 |
|---|
| LocusLink ID | 7352 |
|---|---|
| 22229 | |
| 25708 |
| Alias | SLC25A9 |
|---|---|
| uncoupling protein 3 | |
| Uncoupling protein-3 | |
| UCP-3 | |
| AI645527 | |
| uncoupling protein 3 (mitochondrial, proton carrier) | |
| OTTMUSP00000026173 | |
| OTTMUSP00000026174 | |
| uncoupling protein 3, mitochondrial | |
| Ucp3 | |
| uncoupling protein 3 isoform UCP3L | |
| Mitochondrial uncoupling protein 3 | |
| Mitochondrial uncoupling protein III | |
| Uncoupling protein III | |
| RIKEN cDNA 4930503E15 gene | |
| ucp3l | |
| KIAA1801 | |
| uncoupling protein 3 isoform UCP3S | |
| ucp3s | |
| hypothetical protein FLJ12303 | |
| isoform ucp3l | |
| isoform ucp3s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602044 |
|---|---|
| 601665 |