| URN | urn:agi-llid:7351 |
|---|---|
| Name | UCP2 |
| Description | uncoupling protein 2 (mitochondrial, proton carrier) |
| Connectivity | 246 |
| Notes | Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. |
| Swiss-Prot Accession | P55851 |
|---|---|
| P70406 | |
| Q549J5 | |
| Q8CBU0 | |
| Q9R1U6 | |
| Q9R246 | |
| P56500 |
| Unigene ID | Hs.80658 |
|---|---|
| Mm.171378 | |
| Rn.13333 |
| KEGG ID | hsa:7351 |
|---|---|
| mmu:22228 | |
| rno:54315 |
| Swiss-Prot ID | UCP2_HUMAN |
|---|---|
| UCP2_MOUSE | |
| UCP2_RAT | |
| Q549J5_MOUSE |
| Cell Localization | Mitochondria |
|---|
| GO ID | 0005488 |
|---|---|
| 0006839 | |
| 0015992 | |
| 0000303 | |
| 0006810 | |
| 0016021 | |
| 0016020 | |
| 0005743 | |
| 0005739 | |
| 0005215 | |
| 0005624 |
| Pathway | PPARG Brief |
|---|---|
| Figure 3 CAR 2009 | |
| PPARbeta BCL6 Targets | |
| PPARG Targets | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00026573 |
|---|---|
| IPI00109175 | |
| IPI00648341 | |
| IPI00858064 | |
| IPI00858033 | |
| IPI00857900 | |
| IPI00857609 | |
| IPI00324565 |
| Ariadne Ontology | Respiratory chain |
|---|
| Mouse chromosome position | 7 50.0 cM |
|---|
| GO Molecular Function | binding |
|---|
| Homologene ID | 2516 |
|---|
| Hugo ID | 12518 |
|---|
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane |
| MGI ID | 109354 |
|---|
| Human chromosome position | 11q13 |
|---|
| GO Biological Process | mitochondrial transport |
|---|---|
| transport | |
| proton transport | |
| response to superoxide |
| Rat chromosome position | 1q32 |
|---|
| Group | Respiratory chain |
|---|---|
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| integral to membrane | |
| binding | |
| mitochondrial transport | |
| transport | |
| proton transport | |
| response to superoxide |
| RGD ID | 3932 |
|---|
| LocusLink ID | 7351 |
|---|---|
| 22228 | |
| 54315 |
| Alias | UCPH |
|---|---|
| BMIQ4 | |
| SLC25A8 | |
| uncoupling protein 2 | |
| uncoupling protein 2 (mitochondrial, proton carrier) | |
| OTTMUSP00000026186 | |
| uncoupling protein 2, mitochondrial | |
| Mitochondrial uncoupling protein 2 | |
| Ucp2 | |
| Uncoupling protein-2 | |
| Mitochondrial uncoupling protein II | |
| Uncoupling protein II | |
| LOC119829 | |
| AW108044 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601693 |
|---|---|
| 606641 | |
| 601665 | |
| 607447 |