| URN | urn:agi-llid:3994 |
|---|---|
| Name | FADS2 |
| Description | fatty acid desaturase 2 |
| Connectivity | 36 |
| Notes | The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. |
| Swiss-Prot Accession | O95864 |
|---|---|
| Q9Z0R9 | |
| Q9Z122 |
| Unigene ID | Hs.502745 |
|---|---|
| Mm.38901 | |
| Rn.162483 |
| KEGG ID | mmu:56473 |
|---|---|
| hsa:9415 | |
| rno:83512 |
| EC Number | 1.14.99.25 |
|---|---|
| 1.14.19.3 | |
| 1.14.19.- |
| Swiss-Prot ID | FADS2_HUMAN |
|---|---|
| FADS2_MOUSE | |
| FADS2_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0020037 |
|---|---|
| 0016491 | |
| 0004768 | |
| 0022900 | |
| 0006810 | |
| 0006636 | |
| 0005783 | |
| 0005789 | |
| 0005887 | |
| 0016020 | |
| 0005624 | |
| 0005506 | |
| 0016717 | |
| 0006633 | |
| 0008610 | |
| 0006629 | |
| 0055114 | |
| 0016021 | |
| 0042761 | |
| 0046914 |
| Pathway | NIH Omega 3 |
|---|---|
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00183786 |
|---|---|
| IPI00023484 | |
| IPI00867558 | |
| IPI00129362 | |
| IPI00208106 |
| Ariadne Ontology | Lipid degradation |
|---|
| Mouse chromosome position | 19 B |
|---|
| GO Molecular Function | iron ion binding |
|---|---|
| heme binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | |
| stearoyl-CoA 9-desaturase activity |
| Homologene ID | 3149 |
|---|
| Hugo ID | 3575 |
|---|
| GO Cellular Component | membrane |
|---|---|
| membrane fraction | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane | |
| integral to plasma membrane |
| MGI ID | 1930079 |
|---|
| Human chromosome position | 11q12-q13.1 |
|---|
| GO Biological Process | fatty acid biosynthetic process |
|---|---|
| unsaturated fatty acid biosynthetic process | |
| very-long-chain fatty acid biosynthetic process | |
| electron transport chain | |
| transport | |
| oxidation reduction | |
| lipid biosynthetic process | |
| lipid metabolic process |
| Rat chromosome position | 1q43 |
|---|
| Group | Lipid degradation |
|---|---|
| membrane | |
| membrane fraction | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane | |
| integral to plasma membrane | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | |
| stearoyl-CoA 9-desaturase activity | |
| fatty acid biosynthetic process | |
| unsaturated fatty acid biosynthetic process | |
| very-long-chain fatty acid biosynthetic process | |
| electron transport chain | |
| transport | |
| oxidation reduction | |
| lipid biosynthetic process | |
| lipid metabolic process |
| RGD ID | 68339 |
|---|
| LocusLink ID | 3994 |
|---|---|
| 9415 | |
| 56473 | |
| 83512 |
| Alias | D6D |
|---|---|
| DES6 | |
| TU13 | |
| FADSD6 | |
| LLCDL2 | |
| SLL0262 | |
| fatty acid desaturase 2 | |
| delta-6-desaturase | |
| delta-6 fatty acid desaturase | |
| linoleoyl-CoA desaturase (delta-6-desaturase)-like 2 | |
| Fadsd2 | |
| 2900042M13Rik | |
| MGC93365 | |
| fatty acid desaturase 6 | |
| fatty acid desaturase II | |
| FADS2 | |
| 4833423E24 | |
| linoleoyl-CoA desaturase (delta-6-desaturase)-like II | |
| fatty acid desaturase VI | |
| RIKEN cDNA 2900042M13 gene | |
| Fadsd2s | |
| FADSD6s | |
| LLCDL2s | |
| hypothetical protein 4833423E24 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606149 |
|---|