| URN | urn:agi-llid:2179 |
|---|---|
| Name | ACSL1 |
| Description | acyl-CoA synthetase long-chain family member 1 |
| Connectivity | 99 |
| Notes | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. |
| Swiss-Prot Accession | P33121 |
|---|---|
| Q108N1 | |
| Q108N2 | |
| P41216 | |
| Q6GTG6 | |
| P18163 |
| Unigene ID | Hs.406678 |
|---|---|
| Mm.210323 | |
| Rn.6215 |
| KEGG ID | rno:25288 |
|---|---|
| hsa:2180 | |
| mmu:14081 |
| EC Number | 6.2.1.3 |
|---|
| Swiss-Prot ID | ACSL1_HUMAN |
|---|---|
| ACSL1_MOUSE | |
| ACSL1_RAT | |
| Q6GTG6_MOUSE |
| Cell Localization | Mitochondria |
|---|
| GO ID | 0016874 |
|---|---|
| 0004467 | |
| 0000287 | |
| 0007586 | |
| 0006631 | |
| 0006629 | |
| 0008152 | |
| 0046320 | |
| 0005829 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005792 | |
| 0005741 | |
| 0005739 | |
| 0005778 | |
| 0005777 | |
| 0043758 | |
| 0003824 | |
| 0003987 | |
| 0042493 | |
| 0007584 | |
| 0014070 | |
| 0010033 | |
| 0005886 | |
| 0005625 |
| Pathway | Donna Regulators |
|---|---|
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00012728 |
|---|---|
| IPI00401448 | |
| IPI00815946 | |
| IPI00112549 | |
| IPI00556840 | |
| IPI00856216 | |
| IPI00857226 | |
| IPI00856996 | |
| IPI00857822 | |
| IPI00188989 |
| Ariadne Ontology | Fatty acid oxidation |
|---|
| Mouse chromosome position | 8 B2 |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| magnesium ion binding | |
| ligase activity | |
| acetate-CoA ligase (ADP-forming) activity | |
| acetate-CoA ligase activity | |
| long-chain-fatty-acid-CoA ligase activity |
| Homologene ID | 37561 |
|---|
| Hugo ID | 3569 |
|---|
| GO Cellular Component | membrane |
|---|---|
| soluble fraction | |
| microsome | |
| endoplasmic reticulum membrane | |
| mitochondrion | |
| cytosol | |
| endoplasmic reticulum | |
| peroxisome | |
| peroxisomal membrane | |
| mitochondrial outer membrane | |
| plasma membrane | |
| integral to membrane |
| MGI ID | 102797 |
|---|
| Human chromosome position | 4q34-q35 |
|---|
| GO Biological Process | metabolic process |
|---|---|
| regulation of fatty acid oxidation | |
| fatty acid metabolic process | |
| lipid metabolic process | |
| digestion | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to organic cyclic substance |
| Rat chromosome position | 16q11 |
|---|
| Group | Fatty acid oxidation |
|---|---|
| membrane | |
| soluble fraction | |
| microsome | |
| endoplasmic reticulum membrane | |
| mitochondrion | |
| cytosol | |
| endoplasmic reticulum | |
| peroxisome | |
| peroxisomal membrane | |
| mitochondrial outer membrane | |
| plasma membrane | |
| integral to membrane | |
| catalytic activity | |
| magnesium ion binding | |
| ligase activity | |
| acetate-CoA ligase (ADP-forming) activity | |
| acetate-CoA ligase activity | |
| long-chain-fatty-acid-CoA ligase activity | |
| metabolic process | |
| regulation of fatty acid oxidation | |
| fatty acid metabolic process | |
| lipid metabolic process | |
| digestion | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to organic cyclic substance |
| RGD ID | 2015 |
|---|
| LocusLink ID | 2179 |
|---|---|
| 2180 | |
| 14081 | |
| 25288 |
| Alias | ACS1 |
|---|---|
| LACS | |
| FACL1 | |
| FACL2 | |
| LACS1 | |
| LACS2 | |
| acyl-CoA synthetase long-chain family member 1 | |
| palmitoyl-CoA ligase 2 | |
| paltimoyl-CoA ligase 1 | |
| lignoceroyl-CoA synthase | |
| long-chain acyl-CoA synthetase 1 | |
| long-chain acyl-CoA synthetase 2 | |
| long-chain fatty-acid-coenzyme A ligase 1 | |
| fatty-acid-Coenzyme A ligase, long-chain 1 | |
| fatty-acid-Coenzyme A ligase, long-chain 2 | |
| Acs | |
| Acas | |
| FACS | |
| Acas1 | |
| OTTMUSP00000025909 | |
| OTTMUSP00000025910 | |
| acetate-CoA ligase | |
| acetyl-CoA synthetase | |
| fatty acid Coenzyme A ligase, long chain 2 | |
| acetyl-Coenzyme A synthetase 1 (ADP forming) | |
| COAA | |
| Acyl CoA synthetase, long chain | |
| acetyl-coenzyme a synthetase 1 | |
| acetyl-coenzyme a synthetase I | |
| long-chain fatty-acid-coenzyme A ligase I | |
| ACSL1 | |
| acyl-CoA synthetase long-chain family member I | |
| palmitoyl-CoA ligase II | |
| paltimoyl-CoA ligase I | |
| Long-chain acyl-CoA synthetase 1 | |
| Long-chain-fatty-acid-CoA ligase II | |
| Acas I | |
| Long-chain acyl-CoA synthetase 2 | |
| Long-chain-fatty-acid-CoA ligase 2 | |
| Long-chain-fatty-acid-CoA ligase 1 | |
| Palmitoyl-CoA ligase | |
| acetyl-Coenzyme A synthetase | |
| fatty-acid-Coenzyme A ligase, long-chain | |
| Long-chain-fatty-acid-CoA ligase I | |
| fatty-acid-Coenzyme A ligase, long-chain II | |
| long-chain fatty-acid-Coenzyme A ligase II | |
| fatty-acid-Coenzyme A ligase, long-chain I | |
| ACS I | |
| FACL I | |
| long-chain fatty-acid-Coenzyme A ligase 2 | |
| LACS I | |
| fatty acid coenzyme a ligase | |
| long-chain acyl-CoA synthetase | |
| LOC56355 | |
| LOC91249 | |
| long-chain 1 | |
| long-chain I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 152425 |
|---|