| URN | urn:agi-llid:4363 |
|---|---|
| Name | ABCC1 |
| Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
| Connectivity | 169 |
| Notes | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq] |
| Swiss-Prot Accession | A3RJX2 |
|---|---|
| P33527 | |
| Q68CP7 | |
| Q9BV39 | |
| Q9UQ98 | |
| A5D6P3 | |
| O35379 | |
| Q3UDM1 | |
| Q8BRD0 | |
| Q8C7V6 | |
| Q9JL41 | |
| Q8CG09 | |
| Q810G8 |
| Unigene ID | Hs.709181 |
|---|---|
| Mm.196634 | |
| Rn.10495 |
| KEGG ID | mmu:17250 |
|---|---|
| rno:24565 |
| Swiss-Prot ID | MRP1_MOUSE |
|---|---|
| MRP1_RAT | |
| A5D6P3_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005524 |
|---|---|
| 0016887 | |
| 0042626 | |
| 0000166 | |
| 0005215 | |
| 0042493 | |
| 0006810 | |
| 0005887 | |
| 0016020 | |
| 0005624 | |
| 0017111 | |
| 0016021 | |
| 0015562 | |
| 0034634 | |
| 0034040 | |
| 0005324 | |
| 0015559 | |
| 0016491 | |
| 0046624 | |
| 0008559 | |
| 0060326 | |
| 0043215 | |
| 0046618 | |
| 0006855 | |
| 0043526 | |
| 0055114 | |
| 0033700 | |
| 0015911 | |
| 0030335 | |
| 0006979 | |
| 0034775 | |
| 0055085 | |
| 0042908 | |
| 0016323 | |
| 0005737 | |
| 0005886 |
| Pathway | Toxicology Array |
|---|---|
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00014985 |
|---|---|
| IPI00008338 | |
| IPI00216262 | |
| IPI00216263 | |
| IPI00216264 | |
| IPI00216265 | |
| IPI00216266 | |
| IPI00216267 | |
| IPI00719178 | |
| IPI00008463 | |
| IPI00843930 | |
| IPI00008465 | |
| IPI00129915 | |
| IPI00474038 | |
| IPI00880388 | |
| IPI00880611 | |
| IPI00880749 | |
| IPI00880544 | |
| IPI00331756 | |
| IPI00734748 | |
| IPI00780058 | |
| IPI00778303 | |
| IPI00567040 | |
| IPI00779078 | |
| IPI00782487 | |
| IPI00777539 | |
| IPI00781017 | |
| IPI00780018 | |
| IPI00778672 | |
| IPI00780958 | |
| IPI00768370 |
| Ariadne Ontology | OA transport |
|---|
| Mouse chromosome position | 16 A1 |
|---|
| GO Molecular Function | transporter activity |
|---|---|
| nucleotide binding | |
| ATP binding | |
| oxidoreductase activity | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| lipid-transporting ATPase activity | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| multidrug efflux pump activity | |
| sphingolipid transporter activity | |
| long-chain fatty acid transporter activity | |
| glutathione transmembrane transporter activity | |
| efflux transmembrane transporter activity |
| Homologene ID | 55459 |
|---|
| Hugo ID | 51 |
|---|
| GO Cellular Component | membrane |
|---|---|
| membrane fraction | |
| cytoplasm | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| basolateral plasma membrane |
| MGI ID | 102676 |
|---|
| Human chromosome position | 16p13.1 |
|---|
| GO Biological Process | positive regulation of cell migration |
|---|---|
| neuroprotection | |
| transmembrane transport | |
| cell chemotaxis | |
| multidrug transport | |
| transmembrane glutathione transport | |
| transport | |
| xenobiotic transport | |
| daunorubicin transport | |
| drug export | |
| plasma membrane long-chain fatty acid transport | |
| phospholipid efflux | |
| oxidation reduction | |
| response to drug | |
| response to oxidative stress |
| Rat chromosome position | 10q11 |
|---|
| Group | OA transport |
|---|---|
| membrane | |
| membrane fraction | |
| cytoplasm | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| basolateral plasma membrane | |
| transporter activity | |
| nucleotide binding | |
| ATP binding | |
| oxidoreductase activity | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| lipid-transporting ATPase activity | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| multidrug efflux pump activity | |
| sphingolipid transporter activity | |
| long-chain fatty acid transporter activity | |
| glutathione transmembrane transporter activity | |
| efflux transmembrane transporter activity | |
| positive regulation of cell migration | |
| neuroprotection | |
| transmembrane transport | |
| cell chemotaxis | |
| multidrug transport | |
| transmembrane glutathione transport | |
| transport | |
| xenobiotic transport | |
| daunorubicin transport | |
| drug export | |
| plasma membrane long-chain fatty acid transport | |
| phospholipid efflux | |
| oxidation reduction | |
| response to drug | |
| response to oxidative stress |
| RGD ID | 3112 |
|---|
| LocusLink ID | 4363 |
|---|---|
| 17250 | |
| 24565 |
| Alias | MRP |
|---|---|
| ABCC | |
| GS-X | |
| MRP1 | |
| ABC29 | |
| DKFZp781G125 | |
| DKFZp686N04233 | |
| ATP-binding cassette, sub-family C, member 1 | |
| LTC4 transporter | |
| OTTHUMP00000045904 | |
| leukotriene C(4) transporter | |
| multidrug resistance protein | |
| multiple drug resistance protein 1 | |
| multiple drug resistance-associated protein | |
| Mdrap | |
| Abcc1a | |
| Abcc1b | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 1a | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 1b | |
| Avcc1a | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | |
| multidrug resistance protein 1 | |
| ATP-binding cassette sub-family C ( CFTR/MRP) member 1a | |
| Abcc1 | |
| multidrug resistance protein GS-X | |
| ATP-binding cassette, sub-family C, member 1 isoform 1 | |
| ATP-binding cassette, sub-family C, member 1 isoform I | |
| ATP-binding cassette, sub-family C, member 1 isoform 2 | |
| ATP-binding cassette, sub-family C, member 1 isoform II | |
| ATP-binding cassette, sub-family C, member 1 isoform 3 | |
| ATP-binding cassette, sub-family C, member 1 isoform III | |
| ATP-binding cassette, sub-family C, member 1 isoform 4 | |
| ATP-binding cassette, sub-family C, member 1 isoform IV | |
| ATP-binding cassette, sub-family C, member 1 isoform 5 | |
| ATP-binding cassette, sub-family C, member 1 isoform V | |
| ATP-binding cassette, sub-family C, member 1 isoform 6 | |
| ATP-binding cassette, sub-family C, member 1 isoform VI | |
| ATP-binding cassette, sub-family C, member 1 isoform 7 | |
| ATP-binding cassette, sub-family C, member 1 isoform VII | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member I | |
| multiple drug resistance protein I | |
| Abcc I | |
| Multidrug resistance-associated protein 1 | |
| Multidrug resistance-associated protein I | |
| ATP-binding cassette, sub-family C ( CFTR/MRP), member 1a | |
| ATP-binding cassette, sub-family C, member I | |
| Multidrug resistance-associated protein (MRP) 1 | |
| LOC304706 | |
| LOC363524 | |
| AJ277881 | |
| LOC64052 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 158343 |
|---|