| URN | urn:agi-llid:1374 |
|---|---|
| Name | CPT1A |
| Description | carnitine palmitoyltransferase 1A (liver) |
| Connectivity | 116 |
| Notes | The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. |
| Swiss-Prot Accession | P50416 |
|---|---|
| B2RAQ8 | |
| Q8WZ48 | |
| P97742 | |
| Q7TQD5 | |
| Q3UGT1 | |
| P32198 |
| Unigene ID | Hs.503043 |
|---|---|
| Mm.18522 | |
| Rn.2856 |
| KEGG ID | hsa:1374 |
|---|---|
| mmu:12894 | |
| rno:25757 |
| EC Number | 2.3.1.21 |
|---|
| Swiss-Prot ID | CPT1A_HUMAN |
|---|---|
| CPT1A_MOUSE | |
| CPT1A_RAT | |
| B2RAQ8_HUMAN | |
| Q7TQD5_MOUSE |
| Cell Localization | Mitochondria |
|---|
| GO ID | 0008415 |
|---|---|
| 0004095 | |
| 0016740 | |
| 0006635 | |
| 0006631 | |
| 0006629 | |
| 0006810 | |
| 0016021 | |
| 0016020 | |
| 0005741 | |
| 0005739 | |
| 0005743 | |
| 0009437 | |
| 0042755 | |
| 0006006 | |
| 0001676 | |
| 0031998 | |
| 0046320 | |
| 0050796 | |
| 0005789 | |
| 0005792 | |
| 0019867 |
| Pathway | HepG2 Extracts |
|---|---|
| PPARbeta BCL6 Targets | |
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00032038 |
|---|---|
| IPI00479108 | |
| IPI00330094 | |
| IPI00213538 |
| Ariadne Ontology | Fatty acid oxidation |
|---|
| Mouse chromosome position | 19 2.0 cM |
|---|
| GO Molecular Function | transferase activity |
|---|---|
| acyltransferase activity | |
| carnitine O-palmitoyltransferase activity |
| Homologene ID | 1413 |
|---|
| Hugo ID | 2328 |
|---|
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| endoplasmic reticulum membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial outer membrane | |
| integral to membrane |
| MGI ID | 1098296 |
|---|
| Human chromosome position | 11q13.1-q13.2 |
|---|
| GO Biological Process | regulation of insulin secretion |
|---|---|
| regulation of fatty acid beta-oxidation | |
| regulation of fatty acid oxidation | |
| glucose metabolic process | |
| carnitine metabolic process | |
| fatty acid beta-oxidation | |
| fatty acid metabolic process | |
| long-chain fatty acid metabolic process | |
| transport | |
| lipid metabolic process | |
| eating behavior |
| Rat chromosome position | 1q43 |
|---|
| Group | Fatty acid oxidation |
|---|---|
| membrane | |
| microsome | |
| endoplasmic reticulum membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial outer membrane | |
| integral to membrane | |
| transferase activity | |
| acyltransferase activity | |
| carnitine O-palmitoyltransferase activity | |
| regulation of insulin secretion | |
| regulation of fatty acid beta-oxidation | |
| regulation of fatty acid oxidation | |
| glucose metabolic process | |
| carnitine metabolic process | |
| fatty acid beta-oxidation | |
| fatty acid metabolic process | |
| long-chain fatty acid metabolic process | |
| transport | |
| lipid metabolic process | |
| eating behavior | |
| Liver Lipid Transport |
| RGD ID | 2396 |
|---|
| LocusLink ID | 1374 |
|---|---|
| 12894 | |
| 25757 |
| Alias | CPT1 |
|---|---|
| CPT1-L | |
| L-CPT1 | |
| carnitine palmitoyltransferase 1A | |
| carnitine palmitoyltransferase I, liver | |
| CPTI | |
| C730027G07 | |
| carnitine palmitoyltransferase 1a, liver | |
| L-CPT I | |
| carnitine palmitoyltransferase 1, liver | |
| CPT-Ia | |
| Carnitine palmitoyltransferase 1 alpha, liver isoform | |
| CPT1-Ls | |
| CPTI-L | |
| Carnitine O-palmitoyltransferase I | |
| Carnitine O-palmitoyltransferase I, mitochondrial liver isoform | |
| carnitine palmitoyltransferase 1A (liver) | |
| carnitine palmitoyltransferase I | |
| liver carnitine palmitoyltransferase I | |
| mitochondrial Carnitine O-palmitoyltransferase I liver isoform | |
| carnitine palmitoyltransferase 1 | |
| CPT1A | |
| AA589474 | |
| AA960192 | |
| L-CPT1s | |
| L-CPT Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600528 |
|---|---|
| 255120 |