| URN | urn:agi-llid:10257 |
|---|---|
| Name | ABCC4 |
| Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
| Connectivity | 83 |
| Notes | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq] |
| Swiss-Prot Accession | O15439 |
|---|---|
| Q8IVZ4 | |
| O75555 | |
| Q59GY6 | |
| Q8IUA3 | |
| Q8IWU1 | |
| Q3TZN9 | |
| Q6QMG6 | |
| Q59DL1 | |
| Q6QMG5 | |
| Q91Y23 |
| Unigene ID | Hs.508423 |
|---|---|
| Mm.40537 | |
| Rn.13195 |
| KEGG ID | hsa:10257 |
|---|---|
| mmu:239273 | |
| rno:170924 |
| Swiss-Prot ID | MRP4_HUMAN |
|---|---|
| Q8IVZ4_HUMAN | |
| Q3TZN9_MOUSE | |
| Q6QMG6_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0016404 |
|---|---|
| 0005524 | |
| 0016887 | |
| 0042626 | |
| 0005254 | |
| 0000166 | |
| 0008150 | |
| 0006811 | |
| 0005575 | |
| 0016021 | |
| 0005624 | |
| 0005886 | |
| 0031088 | |
| 0015559 | |
| 0006855 | |
| 0003674 | |
| 0048661 | |
| 0042493 | |
| 0014070 | |
| 0010243 | |
| 0010033 | |
| 0016323 | |
| 0016020 |
| Pathway | Toxicology Array |
|---|---|
| New Pathway | |
| PPARalpha Pathway |
| IPI ID | IPI00006675 |
|---|---|
| IPI00908369 | |
| IPI00654690 | |
| IPI00867698 | |
| IPI00111686 | |
| IPI00421457 |
| Ariadne Ontology | OA transport |
|---|
| Mouse chromosome position | 14 E4 |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| nucleotide binding | |
| ATP binding | |
| ATPase activity, coupled to transmembrane movement of substances | |
| ATPase activity | |
| 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | |
| multidrug efflux pump activity | |
| chloride channel activity |
| Homologene ID | 74563 |
|---|
| Hugo ID | 55 |
|---|
| GO Cellular Component | cellular_component |
|---|---|
| membrane | |
| membrane fraction | |
| platelet dense granule membrane | |
| plasma membrane | |
| integral to membrane | |
| basolateral plasma membrane |
| MGI ID | 2443111 |
|---|
| Human chromosome position | 13q32 |
|---|
| GO Biological Process | biological_process |
|---|---|
| positive regulation of smooth muscle cell proliferation | |
| multidrug transport | |
| ion transport | |
| response to drug | |
| response to organic substance | |
| response to organic nitrogen | |
| response to organic cyclic substance |
| Rat chromosome position | 15q24 |
|---|
| Group | OA transport |
|---|---|
| cellular_component | |
| membrane | |
| membrane fraction | |
| platelet dense granule membrane | |
| plasma membrane | |
| integral to membrane | |
| basolateral plasma membrane | |
| molecular_function | |
| nucleotide binding | |
| ATP binding | |
| ATPase activity, coupled to transmembrane movement of substances | |
| ATPase activity | |
| 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | |
| multidrug efflux pump activity | |
| chloride channel activity | |
| biological_process | |
| positive regulation of smooth muscle cell proliferation | |
| multidrug transport | |
| ion transport | |
| response to drug | |
| response to organic substance | |
| response to organic nitrogen | |
| response to organic cyclic substance |
| RGD ID | 620266 |
|---|
| LocusLink ID | 10257 |
|---|---|
| 239273 | |
| 170924 |
| Alias | MRP4 |
|---|---|
| MOATB | |
| MOAT-B | |
| EST170205 | |
| RP11-74A12.1 | |
| ATP-binding cassette, sub-family C, member 4 | |
| OTTHUMP00000018560 | |
| multidrug resistance-associated protein 4 | |
| multispecific organic anion transporter B | |
| bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) | |
| canalicular multispecific organic anion transporter (ABC superfamily) | |
| D630049P08Rik | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | |
| ABC-tranporter | |
| ATP-binding cassette protein C4 | |
| ATP-binding cassette, sub-family C, member IV | |
| Multidrug resistance-associated protein IV | |
| D630049P08 | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member IV | |
| Abcc4 | |
| MRP/cMOAT-related ABC transporter | |
| ba464i2.1 (atp-binding cassette, sub-family c | |
| atp-binding cassette, sub-family c (cftr\/mrp), member IV | |
| atp-binding cassette, sub-family c (cftr\/mrp), member 4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605250 |
|---|