| References | 2 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:3638::positive |
| TextRef | info:pmid/18627005#abs:5 |
|---|---|
| MedLine Reference | 18627005:4 |
| Sentence | GW0742 and PPARdelta overexpression in hepatocytes induced the expression of insulin-induced gene-1 (Insig-1), an endoplasmic reticulum protein braking SREBP activation, at both the mRNA and the protein levels. |
| CellType | hepatocyte |
| Organ | liver |
|---|---|
| MedLine Reference | 18627005:9 |
| Sentence | Furthermore, overexpression of PPARdelta by intravenous infection with the PPARdelta adenovirus induced the expression of Insig-1, suppressed SREBP-1 activation, and, consequently, ameliorated hepatic steatosis in obese db/db mice. |
| CellLineName | db |