| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5467:out-urn:agi-llid:4843::negative |
|---|---|
| References | 5 |
| Connectivity | 2 |
| Effect | negative |
| CellLineName | RASMCs |
|---|---|
| Organism | Rattus norvegicus |
| Tissue | smooth muscle |
| TextRef | info:pmid/17620284#abs:5 |
| Organ | aorta |
| MedLine Reference | 17620284:4 |
| Sentence | Furthermore, beraprost increased both consensus PPARdelta-responsive element (PPRE)-driven luciferase activity and the binding activity of the PPARdelta to the putative PPRE in the iNOS promoter; nevertheless, it was abolished by PPARdelta antagonists. |
| TextRef | info:pmid/14985344#cont:187 |
|---|---|
| MedLine Reference | 14985344:10186 |
| Sentence | Therefore, it cannot be excluded that its inhibitory action on iNOS may be mediated in part through PPARd. |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i20 p20767 |
| Journal Link | http://www.jbc.org/cgi/content/full/279/20/20767 |
| CellType | macrophage |
| TextRef | info:pmid/12740443#cont:125 |
|---|---|
| MedLine Reference | 12740443:10124 |
| Sentence | Ten micrograms of total RNA was analyzed for expression of the indicated genes by Northern blotting. ( B ) PPARdelta potently inhibits LPS-dependent induction of iNOS and COX2. |
| Journal | PNAS |
| Journal Reference | v100 i11 p6712 |
| Journal Link | http://www.pnas.org/cgi/content/full/100/11/6712 |
| CellType | macrophage |
| Tissue | epithelia |
|---|---|
| TextRef | info:pmid/18375823#cont:89 |
| MedLine Reference | 18375823:10088 |
| Sentence | In vitro studies show that activation of PPARß/d by GW0742 inhibits lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO) activity, and epithelial inflammation ( 67 ). |
| Journal | EBM |
| Journal Reference | v233 i5 p496 |
| Journal Link | http://www.ebmonline.org/cgi/content/full/233/5/496 |
| Tissue | epithelia |
|---|---|
| TextRef | info:pmid/18048767#cont:101 |
| MedLine Reference | 18048767:10100 |
| Sentence | In macrophages, the PPAR-d agonist GW0742 inhibited lipopolysaccharide (LPS)-induced expression of iNOS and COX2. 14,25 However, in other cell types such as epithelial cells, eosinophils, neutrophils, and lymphocytes, the PPAR-d agonist was ineffective in inhibiting inflammatory processes, 26 which indicates that the effect is cell-type specific. |
| Journal | ATVB |
| Journal Reference | v28 i2 p315 |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/28/2/315 |
| CellType | macrophage |