| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5467:out-urn:agi-llid:7352::positive |
|---|---|
| References | 7 |
| Connectivity | 2 |
| Effect | positive |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/17389766#abs:5 |
| Organ | heart |
| MedLine Reference | 17389766:4 |
| Sentence | UCP3 gene is regulated by PPARalpha and PPARdelta in the muscle, heart, and adipose tissues. |
| Tissue | skeletal muscle |
|---|---|
| TextRef | info:pmid/12843208#abs:2 |
| MedLine Reference | 12843208:1 |
| Sentence | Peroxisome proliferator-activated receptor (PPAR)alpha and PPARdelta (also known as PPARbeta) mediate human UCP3 gene regulation by fatty acids through a direct-repeat (DR-1) element in the promoter. |
| CellLineName | L6 |
|---|---|
| TextRef | info:pmid/16857752#cont:105 |
| MedLine Reference | 16857752:10104 |
| Sentence | D, ChiP analysis of PPARd binding to the mouse UCP3 gene promoter. |
| Journal | Endocrinology |
| Journal Reference | v147 i10 p4695 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/147/10/4695 |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/18509063#cont:62 |
| MedLine Reference | 18509063:10061 |
| Sentence | Transcription of LCAD and UCP3 is regulated by PPARd ( 34 , 35 ). |
| Journal | PNAS |
| Journal Reference | v105 i22 p7815 |
| Journal Link | http://www.pnas.org/content/105/22/7815.full |
| CellLineName | L6 |
|---|---|
| TextRef | info:pmid/17584959#cont:180 |
| MedLine Reference | 17584959:10179 |
| Sentence | Furthermore, UCP-3 expression is mainly enhanced by PPAR-d activation in L6 myocytes ( 36 ). |
| Journal | Endocrinology |
| Journal Reference | v148 i10 p4548 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/148/10/4548 |
| CellType | myocyte |
| Tissue | skeletal muscle |
|---|---|
| TextRef | info:pmid/17478558#cont:107 |
| MedLine Reference | 17478558:10106 |
| Sentence | These data show that activation of the residing PPARd can induce UCP3 expression, without the need for a preceding increase in the PPARd mRNA level. |
| Journal | Endocrinology |
| Journal Reference | v148 i8 p4064 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/148/8/4064 |
| CellLineName | L6 |
|---|---|
| Organism | Homo sapiens |
| TextRef | info:pmid/12118038#cont:215 |
| MedLine Reference | 12118038:10214 |
| Sentence | Our results are consistent with recent studies showing that activation of PPARdelta induces mRNA expression of UCP2 and UCP3 in human and L6 myotubes, respectively. |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i29 p26089 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/29/26089 |
| CellType | myotube |