| References | 2 |
|---|---|
| Connectivity | 2 |
| Effect | unknown |
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:207::unknown |
| MedLine Reference | 12963727:10115 |
|---|---|
| Sentence | This activity was traced to PPARbeta/delta-mediated transcriptional up-regulation of the expression of ILK and PDK1, leading to activation of the anti-apoptotic Akt1 signaling pathway ( 17 ). |
| CellType | keratinocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i43 p41589 |
| Journal Link | http://www.jbc.org/cgi/content/full/278/43/41589 |
| Organ | skin |
|---|---|
| MedLine Reference | 16077002:10131 |
| Sentence | Beatrice Desvergne (University of Lausanne, Switzerland) presented a pathway in skin whereby pro-inflammatory cytokines such as TNFa, which are produced during wound healing, generate endogenous PPARd ligands that allow induction of Akt1 expression and prevent apoptosis. |
| Journal | Genes & Dev |
| Journal Reference | v19 i15 p1737 |
| Journal Link | http://www.genesdev.org/cgi/content/full/19/15/1737 |