| URN | urn:agi-llid:5743 |
|---|---|
| Name | PTGS2 |
| Description | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| Connectivity | 1781 |
| Notes | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS2, which shows 86% - 89% amino acid sequence identity with mouse, rat, sheep, bovine, horse and rabit PTGS2 proteins, respectively. Human PTGS2 is expressed in a limited number of cell types and regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. The expression of this gene is deregulated in epithelial tumors. |
| Swiss-Prot Accession | A8K802 |
|---|---|
| P35354 | |
| Q6ZYK7 | |
| Q8IZA9 | |
| Q9NNY7 | |
| Q05769 | |
| Q543K3 | |
| Q3UMR6 | |
| Q7TMV2 | |
| P35355 | |
| Q63124 | |
| Q8CIP1 |
| Unigene ID | Hs.196384 |
|---|---|
| Mm.292547 | |
| Rn.44369 |
| KEGG ID | hsa:5743 |
|---|---|
| mmu:19225 | |
| rno:29527 |
| EC Number | 1.14.99.1 |
|---|
| Swiss-Prot ID | PGH2_HUMAN |
|---|---|
| PGH2_MOUSE | |
| PGH2_RAT | |
| A8K802_HUMAN | |
| Q543K3_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0020037 |
|---|---|
| 0008289 | |
| 0046872 | |
| 0016491 | |
| 0016702 | |
| 0004601 | |
| 0004666 | |
| 0005515 | |
| 0042640 | |
| 0006928 | |
| 0019371 | |
| 0006633 | |
| 0008285 | |
| 0055114 | |
| 0008217 | |
| 0050727 | |
| 0006979 | |
| 0005737 | |
| 0005783 | |
| 0005788 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0005634 | |
| 0043234 | |
| 0005506 | |
| 0030282 | |
| 0030216 | |
| 0008610 | |
| 0001516 | |
| 0042127 | |
| 0046697 | |
| 0007566 | |
| 0006954 | |
| 0007613 | |
| 0051926 | |
| 0032227 | |
| 0030728 | |
| 0043065 | |
| 0008284 | |
| 0048661 | |
| 0045987 | |
| 0031915 | |
| 0051968 | |
| 0045907 | |
| 0051726 | |
| 0034097 | |
| 0042493 | |
| 0032355 | |
| 0009750 | |
| 0051384 | |
| 0032496 | |
| 0010042 | |
| 0014070 | |
| 0010243 | |
| 0010033 | |
| 0033280 | |
| 0005901 | |
| 0005635 | |
| 0009053 | |
| 0005615 |
| Pathway | NIH Omega 3 |
|---|---|
| PPARG Brief | |
| Figure 3 CAR 2009 | |
| PPARbeta BCL6 Targets | |
| PPARG Targets | |
| FXR Targets | |
| Toxicology Array | |
| New Pathway | |
| PPARalpha Pathway | |
| PPARalpha Targets | |
| PPARbeta Targets |
| IPI ID | IPI00018109 |
|---|---|
| IPI00447478 | |
| IPI00816025 | |
| IPI00308785 | |
| IPI00462137 | |
| IPI00197645 |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|
| Mouse chromosome position | 1 76.2 cM |
|---|
| GO Molecular Function | peroxidase activity |
|---|---|
| protein binding | |
| lipid binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | |
| prostaglandin-endoperoxide synthase activity |
| Homologene ID | 31000 |
|---|
| Hugo ID | 9605 |
|---|
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| nuclear envelope | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| endoplasmic reticulum | |
| nucleus | |
| endoplasmic reticulum lumen | |
| caveola | |
| protein complex |
| MGI ID | 97798 |
|---|
| Human chromosome position | 1q25.2-q25.3 |
|---|
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| negative regulation of synaptic transmission, dopaminergic | |
| negative regulation of calcium ion transport | |
| positive regulation of cell proliferation | |
| positive regulation of synaptic transmission, glutamatergic | |
| positive regulation of apoptosis | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| regulation of cell cycle | |
| regulation of cell proliferation | |
| positive regulation of synaptic plasticity | |
| regulation of inflammatory response | |
| regulation of blood pressure | |
| cell motion | |
| keratinocyte differentiation | |
| fatty acid biosynthetic process | |
| prostaglandin biosynthetic process | |
| cyclooxygenase pathway | |
| embryo implantation | |
| bone mineralization | |
| decidualization | |
| anagen | |
| oxidation reduction | |
| lipid biosynthetic process | |
| response to lipopolysaccharide | |
| ovulation | |
| memory | |
| response to drug | |
| response to organic substance | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to manganese ion | |
| response to vitamin D | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to fructose stimulus | |
| inflammatory response |
| Rat chromosome position | 13q21 |
|---|
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| membrane | |
| microsome | |
| nuclear envelope | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| endoplasmic reticulum | |
| nucleus | |
| endoplasmic reticulum lumen | |
| caveola | |
| protein complex | |
| peroxidase activity | |
| protein binding | |
| lipid binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | |
| prostaglandin-endoperoxide synthase activity | |
| negative regulation of cell proliferation | |
| negative regulation of synaptic transmission, dopaminergic | |
| negative regulation of calcium ion transport | |
| positive regulation of cell proliferation | |
| positive regulation of synaptic transmission, glutamatergic | |
| positive regulation of apoptosis | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| regulation of cell cycle | |
| regulation of cell proliferation | |
| positive regulation of synaptic plasticity | |
| regulation of inflammatory response | |
| regulation of blood pressure | |
| cell motion | |
| keratinocyte differentiation | |
| fatty acid biosynthetic process | |
| prostaglandin biosynthetic process | |
| cyclooxygenase pathway | |
| embryo implantation | |
| bone mineralization | |
| decidualization | |
| anagen | |
| oxidation reduction | |
| lipid biosynthetic process | |
| response to lipopolysaccharide | |
| ovulation | |
| memory | |
| response to drug | |
| response to organic substance | |
| response to cytokine stimulus | |
| response to oxidative stress | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to manganese ion | |
| response to vitamin D | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| response to fructose stimulus | |
| inflammatory response |
| RGD ID | 620349 |
|---|
| LocusLink ID | 5743 |
|---|---|
| 19225 | |
| 29527 |
| Alias | COX2 |
|---|---|
| COX-2 | |
| PHS-2 | |
| PGG/HS | |
| PGHS-2 | |
| hCox-2 | |
| GRIPGHS | |
| prostaglandin-endoperoxide synthase 2 | |
| cyclooxygenase 2b | |
| OTTHUMP00000033524 | |
| prostaglandin G/H synthase and cyclooxygenase | |
| Pghs2 | |
| TIS10 | |
| cyclooxygenase 2 | |
| cyclooxygenase-2 | |
| prostaglandin G/H synthase | |
| prostaglandin-endoperoxide synthase II | |
| 1DDX_B | |
| 1DDX_A | |
| 1DDX_As | |
| 1DDX_Bs | |
| hCox IIs | |
| PGHS IIs | |
| Cyclooxygenase -2 | |
| PGH synthase 2 | |
| PHS II | |
| Prostaglandin H2 synthase 2 | |
| Prostaglandin G/H synthase 2 precursor | |
| Ptgs2 | |
| TIS10/PGS-2 | |
| PGS-2/TIS10 | |
| PGH synthase II | |
| prostaglandin G/H synthase and cyclooxygenase II | |
| prostaglandin G/H synthase and cyclooxygenase 2 | |
| Prostaglandin H2 synthase II | |
| Cyclooxygenase II | |
| hCox II | |
| PGHS II | |
| prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600262 |
|---|