Protein MSR1

URN	urn:agi-llid:4481
Name	MSR1
Description	macrophage scavenger receptor 1
Connectivity	245
Notes	This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Swiss-Prot ID	MSRE_HUMAN
	Q8CED7_MOUSE

Cell Localization	Plasma membrane

Pathway	PPARG Targets
	PPARbeta Targets

Ariadne Ontology	Lipid transport
	Endocytosis

Mouse chromosome position	8 20.0 cM

GO Molecular Function	molecular_function
	protein binding
	low-density lipoprotein binding
	receptor activity
	scavenger receptor activity

Homologene ID	12822

Hugo ID	7376

GO Cellular Component	membrane
	cytoplasmic vesicle
	cytosol
	plasma membrane
	integral to membrane
	integral to plasma membrane
	low-density lipoprotein particle

MGI ID	98257

Human chromosome position	8p22

GO Biological Process	positive regulation of foam cell differentiation
	lipoprotein particle clearance
	endocytosis
	receptor-mediated endocytosis
	lipoprotein transport
	cholesterol transport
	response to chemical stimulus

Rat chromosome position	16q12.1

Group	Lipid transport
	Endocytosis
	membrane
	cytoplasmic vesicle
	cytosol
	plasma membrane
	integral to membrane
	integral to plasma membrane
	low-density lipoprotein particle
	molecular_function
	protein binding
	low-density lipoprotein binding
	receptor activity
	scavenger receptor activity
	positive regulation of foam cell differentiation
	lipoprotein particle clearance
	endocytosis
	receptor-mediated endocytosis
	lipoprotein transport
	cholesterol transport
	response to chemical stimulus

RGD ID	1564316

Alias	SR-A
	CD204
	phSR1
	phSR2
	SCARA1
	macrophage scavenger receptor 1
	OTTHUMP00000120049
	OTTHUMP00000120050
	scavenger receptor class A, member 1
	macrophage scavenger receptor type III
	macrophage acetylated LDL receptor I and II
	MSR
	Scvr
	MRS-A
	MSR-A
	SR-AI
	SR-AII
	RGD1564316
	Macrophage acetylated LDL receptor I and II
	Macrophage scavenger receptor
	Macrophage scavenger receptor types I and II
	scavenger receptor A
	MSR I
	phSR I
	SCARA I
	macrophage scavenger receptor I
	scavenger receptor class A, member I
	MSR1
	Macrophage scavenger receptors
	SR(A)
	SRA
	sr-aiii
	SCARA1s
	scavenger receptor type A SR-A
	scavenger receptor class A
	SCARA Is

OMIM ID	153622
	176807