| URN | urn:agi-llid:2152 |
|---|---|
| Name | F3 |
| Description | coagulation factor III (thromboplastin, tissue factor) |
| Connectivity | 624 |
| Notes | This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. [provided by RefSeq] |
| Swiss-Prot Accession | P13726 |
|---|---|
| Q86SE7 | |
| Q86WH3 | |
| Q86WH4 | |
| Q8NCW7 | |
| P20352 | |
| Q6RFS9 | |
| Q8R3Q1 | |
| Q66HI4 | |
| P42533 |
| Unigene ID | Hs.62192 |
|---|---|
| Mm.273188 | |
| Rn.9980 |
| KEGG ID | rno:25584 |
|---|
| Swiss-Prot ID | TF_HUMAN |
|---|---|
| Q66HI4_RAT |
| Cell Localization | Plasma membrane |
|---|---|
| Extracellular |
| GO ID | 0007598 |
|---|---|
| 0016021 | |
| 0005886 | |
| 0007596 | |
| 0016020 |
| Pathway | PPARbeta Targets |
|---|
| IPI ID | IPI00010338 |
|---|---|
| IPI00384454 | |
| IPI00118069 | |
| IPI00462790 | |
| IPI00197592 | |
| IPI00471890 |
| Ariadne Ontology | Receptors |
|---|---|
| Coagulation factor |
| Mouse chromosome position | 3 50.0 cM |
|---|
| Homologene ID | 1511 |
|---|
| Hugo ID | 3541 |
|---|
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane |
| MGI ID | 88381 |
|---|
| Human chromosome position | 1p22-p21 |
|---|
| GO Biological Process | blood coagulation |
|---|---|
| blood coagulation, extrinsic pathway |
| Rat chromosome position | 2q41 |
|---|
| Group | Receptors |
|---|---|
| Coagulation factor | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| blood coagulation | |
| blood coagulation, extrinsic pathway |
| RGD ID | 2587 |
|---|
| LocusLink ID | 2152 |
|---|---|
| 14066 | |
| 25584 |
| Alias | TF |
|---|---|
| TFA | |
| CD142 | |
| coagulation factor III | |
| tissue factor | |
| OTTHUMP00000012426 | |
| Cf3 | |
| Cf-3 | |
| AA409063 | |
| MGC93621 | |
| coagulation factor III (thromboplastin, tissue factor) | |
| coagulation factor 3 | |
| CD142 antigen | |
| Coagulation factor F3 | |
| coagulating factor 3 | |
| TF_HUMAN | |
| Thromboplastin | |
| Cf III | |
| coagulating factor III | |
| coagulating factor F3 | |
| coagulating factor III (thromboplastin, tissue factor) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 134390 |
|---|