| URN | urn:agi-llid:5734 |
|---|---|
| Name | PTGER4 |
| Description | prostaglandin E receptor 4 (subtype EP4) |
| Connectivity | 258 |
| Notes | The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. |
| Swiss-Prot Accession | A0PJF5 |
|---|---|
| P35408 | |
| Q91VE4 | |
| P32240 | |
| Q3UM94 | |
| Q8BZK1 | |
| P43114 | |
| Q7TSX4 |
| Unigene ID | Hs.199248 |
|---|---|
| Mm.18509 | |
| Rn.16062 |
| KEGG ID | hsa:5734 |
|---|---|
| mmu:19219 | |
| rno:84023 |
| Swiss-Prot ID | PE2R4_HUMAN |
|---|---|
| PE2R4_MOUSE | |
| PE2R4_RAT | |
| A0PJF5_HUMAN | |
| Q91VE4_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004930 |
|---|---|
| 0004957 | |
| 0004872 | |
| 0007186 | |
| 0007188 | |
| 0006955 | |
| 0030278 | |
| 0007165 | |
| 0016021 | |
| 0005886 | |
| 0004955 | |
| 0004871 | |
| 0007189 | |
| 0016020 | |
| 0001584 |
| Pathway | PPARbeta BCL6 Targets |
|---|---|
| PPARbeta Targets |
| IPI ID | IPI00018648 |
|---|---|
| IPI00136545 | |
| IPI00882277 | |
| IPI00324950 |
| Ariadne Ontology | GPCR-GsCR |
|---|
| Mouse chromosome position | 15 6.4 cM |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| receptor activity | |
| G-protein coupled receptor activity | |
| prostaglandin receptor activity | |
| prostaglandin E receptor activity |
| Homologene ID | 20261 |
|---|
| Hugo ID | 9596 |
|---|
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane |
| MGI ID | 104311 |
|---|
| Human chromosome position | 5p13.1 |
|---|
| GO Biological Process | signal transduction |
|---|---|
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| regulation of ossification | |
| immune response |
| Rat chromosome position | 2q16 |
|---|
| Group | GPCR-GsCR |
|---|---|
| membrane | |
| plasma membrane | |
| integral to membrane | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| prostaglandin receptor activity | |
| prostaglandin E receptor activity | |
| signal transduction | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| regulation of ossification | |
| immune response |
| RGD ID | 628641 |
|---|
| LocusLink ID | 5734 |
|---|---|
| 19219 | |
| 84023 |
| Alias | EP4 |
|---|---|
| EP4R | |
| MGC126583 | |
| prostaglandin E receptor 4, subtype EP4 | |
| PGE receptor, EP4 subtype | |
| prostaglandin E2 receptor | |
| Ptgerep4 | |
| prostaglandin E receptor EP4 subtype | |
| prostaglandin E receptor 4 (EP4 subtype) | |
| Ptger | |
| prostaglandin E2 receptor type 4 | |
| Prostanoid EP4 receptor | |
| prostaglandin EP4 receptors | |
| Prostanoid EP4 receptors | |
| PGE receptor, EP4 subtype | |
| Prostaglandin E2 receptor, EP4 subtype | |
| prostaglandin EP4 receptor | |
| Ptger4 | |
| prostaglandin E receptor 4 | |
| prostaglandin E receptor 4 (subtype EP4) | |
| ep4 subtype | |
| subtype ep4 | |
| EP4 receptor | |
| EP4 receptors | |
| Ptger4s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601586 |
|---|