Protein APOB

URN	urn:agi-llid:338
Name	APOB
Description	apolipoprotein B (including Ag(x) antigen)
Connectivity	441
Notes	This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq]

EC Number	3.5.4.5

Cell Localization	Plasma membrane

Pathway	PPARbeta Targets

Ariadne Ontology	Lipid transport

Mouse chromosome position	12 A1.1

GO Molecular Function	protein binding
	lipid binding
	heparin binding
	phospholipid binding
	protein heterodimerization activity
	low-density lipoprotein receptor binding
	lipid transporter activity
	cholesterol transporter activity

Homologene ID	328

Hugo ID	603

GO Cellular Component	extracellular region
	microsome
	vesicle membrane
	clathrin-coated endocytic vesicle membrane
	endoplasmic reticulum
	endosome lumen
	endosome membrane
	nucleus
	endoplasmic reticulum lumen
	plasma membrane
	extracellular space
	chylomicron
	low-density lipoprotein particle
	chylomicron remnant
	mature chylomicron
	intermediate-density lipoprotein particle
	very-low-density lipoprotein particle
	vesicle lumen

MGI ID	88052

Human chromosome position	2p24-p23

GO Biological Process	very-low-density lipoprotein particle assembly
	positive regulation of foam cell differentiation
	positive regulation of lipid metabolic process
	regulation of cholesterol biosynthetic process
	cholesterol homeostasis
	sperm motility
	low-density lipoprotein particle clearance
	low-density lipoprotein particle remodeling
	cholesterol metabolic process
	steroid metabolic process
	lipoprotein biosynthetic process
	triglyceride catabolic process
	triglyceride mobilization
	lipoprotein metabolic process
	lipoprotein catabolic process
	post-embryonic development
	artery morphogenesis
	nervous system development
	in utero embryonic development
	lipoprotein transport
	lipid transport
	cholesterol transport
	lipid catabolic process
	lipid metabolic process
	fertilization
	spermatogenesis
	response to organic substance
	response to selenium ion
	response to carbohydrate stimulus

Rat chromosome position	6q14

Group	Lipid transport
	extracellular region
	microsome
	vesicle membrane
	clathrin-coated endocytic vesicle membrane
	endoplasmic reticulum
	endosome lumen
	endosome membrane
	nucleus
	endoplasmic reticulum lumen
	plasma membrane
	extracellular space
	chylomicron
	low-density lipoprotein particle
	chylomicron remnant
	mature chylomicron
	intermediate-density lipoprotein particle
	very-low-density lipoprotein particle
	vesicle lumen
	protein binding
	lipid binding
	heparin binding
	phospholipid binding
	protein heterodimerization activity
	low-density lipoprotein receptor binding
	lipid transporter activity
	cholesterol transporter activity
	very-low-density lipoprotein particle assembly
	positive regulation of foam cell differentiation
	positive regulation of lipid metabolic process
	regulation of cholesterol biosynthetic process
	cholesterol homeostasis
	sperm motility
	low-density lipoprotein particle clearance
	low-density lipoprotein particle remodeling
	cholesterol metabolic process
	steroid metabolic process
	lipoprotein biosynthetic process
	triglyceride catabolic process
	triglyceride mobilization
	lipoprotein metabolic process
	lipoprotein catabolic process
	post-embryonic development
	artery morphogenesis
	nervous system development
	in utero embryonic development
	lipoprotein transport
	lipid transport
	cholesterol transport
	lipid catabolic process
	lipid metabolic process
	fertilization
	spermatogenesis
	response to organic substance
	response to selenium ion
	response to carbohydrate stimulus

RGD ID	2129

Alias	FLDB
	apolipoprotein B
	apoB-48
	apoB-100
	OTTHUMP00000115994
	apolipoprotein B48
	AI315052
	MGC176318
	mCG_129875
	Aa1064
	Ac1-060
	apolipoprotein B PI
	apolipoprotein B-48
	apolipoprotein B-100
	Apo B-100
	Apolipoprotein B-100 precursor
	APOB
	apolipoprotein B (including Ag(x) antigen)
	AA-1064
	AA(1064)
	AA 1064
	apo B
	apoB-48s

OMIM ID	107730
	144010