| URN | urn:agi-llid:5733 |
|---|---|
| Name | PTGER3 |
| Description | prostaglandin E receptor 3 (subtype EP3) |
| Connectivity | 189 |
| Notes | The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported. [provided by RefSeq] |
| Swiss-Prot Accession | O00325 |
|---|---|
| B0AZN4 | |
| P43115 | |
| B1AK19 | |
| Q147U0 | |
| Q147X8 | |
| Q5CZ57 | |
| Q5CZ59 | |
| Q5CZ60 | |
| Q5CZ61 | |
| Q5CZ62 | |
| Q5CZ63 | |
| Q5CZ64 | |
| Q6TTN3 | |
| Q9UBW3 |
| Unigene ID | Hs.445000 |
|---|
| KEGG ID | hsa:5733 |
|---|
| Swiss-Prot ID | PE2R3_HUMAN |
|---|---|
| B0AZN4_HUMAN | |
| B1AK19_HUMAN | |
| O00325_HUMAN |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004930 |
|---|---|
| 0004879 | |
| 0004957 | |
| 0007186 | |
| 0008219 | |
| 0007165 | |
| 0006351 | |
| 0005887 | |
| 0005635 | |
| 0005886 |
| Pathway | PPARbeta Targets |
|---|
| IPI ID | IPI00411362 |
|---|---|
| IPI00844529 | |
| IPI00395012 | |
| IPI00395013 | |
| IPI00889746 | |
| IPI00221021 | |
| IPI00394835 | |
| IPI00871625 | |
| IPI00478116 | |
| IPI00783234 | |
| IPI00554795 | |
| IPI00554479 | |
| IPI00554511 | |
| IPI00375543 | |
| IPI00479636 |
| Ariadne Ontology | GPCR-Other |
|---|
| GO Molecular Function | ligand-dependent nuclear receptor activity |
|---|---|
| G-protein coupled receptor activity | |
| prostaglandin E receptor activity |
| Hugo ID | 9595 |
|---|
| GO Cellular Component | nuclear envelope |
|---|---|
| plasma membrane | |
| integral to plasma membrane |
| Human chromosome position | 1p31.2 |
|---|
| GO Biological Process | signal transduction |
|---|---|
| G-protein coupled receptor protein signaling pathway | |
| cell death | |
| transcription, DNA-dependent |
| Group | GPCR-Other |
|---|---|
| nuclear envelope | |
| plasma membrane | |
| integral to plasma membrane | |
| ligand-dependent nuclear receptor activity | |
| G-protein coupled receptor activity | |
| prostaglandin E receptor activity | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| cell death | |
| transcription, DNA-dependent |
| LocusLink ID | 5733 |
|---|
| Alias | EP3 |
|---|---|
| EP3e | |
| EP3-I | |
| EP3-II | |
| EP3-IV | |
| EP3-III | |
| MGC27302 | |
| MGC141828 | |
| MGC141829 | |
| prostaglandin E receptor 3, subtype EP3 | |
| OTTHUMP00000011033 | |
| OTTHUMP00000011034 | |
| OTTHUMP00000011035 | |
| prostanoid EP3 receptor | |
| PGE receptor, EP3 subtype | |
| prostaglandin E2 receptor | |
| prostaglandin receptor (PGE-2) | |
| prostaglandin E receotor EP3 subtype 3 isoform | |
| Rat kidney prostaglandin EP3 receptor | |
| rEP3a | |
| Pgerep3 | |
| Prostaglandin E receptor 3, EP3 subtype | |
| Prostaglandin E2 receptor, EP3 subtype | |
| prostaglandin EP3 receptor | |
| Prostaglandin E receptor 3, subtype | |
| Ptger3 | |
| rEP3b | |
| Rat kidney prostaglandin EP3 receptors | |
| prostaglandin E2 receptors | |
| prostaglandin EP3 receptors | |
| Prostanoid EP3 receptors | |
| prostaglandin E receptor III | |
| prostaglandin E receptor 3 (subtype EP3) | |
| prostaglandin E receptor 3 | |
| ep3 subtype | |
| prostaglandin E receptor EP3 subtype | |
| EP3 receptor | |
| EP3 receptors | |
| Ptgerep3 | |
| Ptger3s |
| Organism | Homo sapiens |
|---|
| OMIM ID | 176806 |
|---|