| URN | urn:agi-llid:9619 |
|---|---|
| Name | ABCG1 |
| Description | ATP-binding cassette, sub-family G (WHITE), member 1 |
| Connectivity | 88 |
| Notes | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. |
| Swiss-Prot Accession | P45844 |
|---|---|
| O43576 | |
| Q0VDW9 | |
| Q64343 | |
| Q9EPG9 |
| Unigene ID | Hs.124649 |
|---|---|
| Mm.15691 | |
| Mm.470747 | |
| Rn.8398 |
| KEGG ID | hsa:9619 |
|---|---|
| mmu:11307 | |
| rno:85264 |
| Swiss-Prot ID | ABCG1_HUMAN |
|---|---|
| ABCG1_MOUSE | |
| Q0VDW9_MOUSE | |
| Q9EPG9_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0043531 |
|---|---|
| 0005524 | |
| 0016887 | |
| 0015485 | |
| 0017127 | |
| 0034437 | |
| 0000166 | |
| 0005543 | |
| 0005548 | |
| 0046982 | |
| 0042803 | |
| 0034041 | |
| 0019534 | |
| 0042987 | |
| 0033344 | |
| 0042632 | |
| 0008203 | |
| 0009720 | |
| 0010742 | |
| 0034436 | |
| 0032367 | |
| 0006869 | |
| 0033700 | |
| 0055091 | |
| 0045542 | |
| 0045834 | |
| 0045449 | |
| 0010033 | |
| 0043691 | |
| 0005794 | |
| 0000139 | |
| 0005783 | |
| 0005789 | |
| 0005768 | |
| 0005887 | |
| 0005886 | |
| 0017111 | |
| 0030301 | |
| 0006810 | |
| 0016021 | |
| 0016020 | |
| 0008565 | |
| 0015031 | |
| 0005615 |
| Pathway | PPARG Brief |
|---|---|
| PPARG Targets | |
| Toxicology Array | |
| PPARbeta Targets |
| IPI ID | IPI00220758 |
|---|---|
| IPI00220759 | |
| IPI00220760 | |
| IPI00220762 | |
| IPI00333761 | |
| IPI00335646 | |
| IPI00024089 | |
| IPI00414196 | |
| IPI00790641 | |
| IPI00133416 | |
| IPI00189036 |
| Ariadne Ontology | Cholesterol export |
|---|
| Mouse chromosome position | 17 |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| phospholipid binding | |
| cholesterol binding | |
| ADP binding | |
| ATP binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| sterol-transporting ATPase activity | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| toxin transporter activity | |
| phospholipid transporter activity | |
| cholesterol transporter activity | |
| glycoprotein transporter activity |
| Homologene ID | 21022 |
|---|
| Hugo ID | 73 |
|---|
| GO Cellular Component | membrane |
|---|---|
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| endosome | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MGI ID | 107704 |
|---|
| Human chromosome position | 21q22.3 |
|---|
| GO Biological Process | positive regulation of cholesterol biosynthetic process |
|---|---|
| positive regulation of lipid metabolic process | |
| regulation of transcription | |
| phospholipid homeostasis | |
| cholesterol homeostasis | |
| foam cell differentiation | |
| intracellular cholesterol transport | |
| cholesterol metabolic process | |
| amyloid precursor protein catabolic process | |
| transport | |
| glycoprotein transport | |
| lipid transport | |
| phospholipid efflux | |
| cholesterol transport | |
| cholesterol efflux | |
| reverse cholesterol transport | |
| detection of hormone stimulus | |
| response to organic substance |
| Rat chromosome position | 20p12 |
|---|
| Group | Cholesterol export |
|---|---|
| membrane | |
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| endosome | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| nucleotide binding | |
| phospholipid binding | |
| cholesterol binding | |
| ADP binding | |
| ATP binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| sterol-transporting ATPase activity | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| toxin transporter activity | |
| phospholipid transporter activity | |
| cholesterol transporter activity | |
| glycoprotein transporter activity | |
| positive regulation of cholesterol biosynthetic process | |
| positive regulation of lipid metabolic process | |
| regulation of transcription | |
| phospholipid homeostasis | |
| cholesterol homeostasis | |
| foam cell differentiation | |
| intracellular cholesterol transport | |
| cholesterol metabolic process | |
| amyloid precursor protein catabolic process | |
| transport | |
| glycoprotein transport | |
| lipid transport | |
| phospholipid efflux | |
| cholesterol transport | |
| cholesterol efflux | |
| reverse cholesterol transport | |
| detection of hormone stimulus | |
| response to organic substance |
| RGD ID | 620294 |
|---|
| LocusLink ID | 9619 |
|---|---|
| 11307 | |
| 85264 |
| Alias | ABC8 |
|---|---|
| WHITE1 | |
| MGC34313 | |
| ATP-binding cassette sub-family G member 1 | |
| ABC transporter 8 | |
| OTTHUMP00000109322 | |
| homolog of Drosophila white | |
| ATP-binding cassette transporter 8 | |
| ATP-binding cassette transporter member 1 of subfamily G | |
| white protein homolog (ATP-binding cassette transporter 8) | |
| White | |
| AW413978 | |
| MGC141022 | |
| ATP-binding cassette, subfamily G, member 1 | |
| OTTMUSP00000031072 | |
| ATP-binding cassette 8 | |
| ATP-binding cassette, sub-family G (WHITE), member 1 | |
| Abcg1 | |
| ATP-binding cassette 8 (homolog of Drosophila white) | |
| ATP-binding cassette sub-family G member 1 isoform b | |
| ATP-binding cassette, sub-family G, member 1 | |
| White protein homolog | |
| WHT1 | |
| ATP-binding cassette VIII | |
| ABC transporter VIII | |
| ATP-binding cassette transporter VIII | |
| homolog of white | |
| ATP-binding cassette, sub-family G, member I | |
| ATP-binding cassette, subfamily G, member I | |
| Abcg I | |
| WHT I | |
| ATP-binding cassette, sub-family G (WHITE), member I | |
| ATP-binding cassette sub-family G member 1 isoform a | |
| WHITE I | |
| White homolog | |
| WHITE1s | |
| WHITE Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603076 |
|---|