| URN | urn:agi-llid:1268 |
|---|---|
| Name | CNR1 |
| Description | cannabinoid receptor 1 (brain) |
| Connectivity | 481 |
| Notes | This gene encodes a protein that is one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] |
| Swiss-Prot Accession | B2R9T4 |
|---|---|
| P21554 | |
| Q5JVL5 | |
| Q506J9 | |
| Q9BYY6 | |
| B1AZT0 | |
| P47746 | |
| Q99NU3 | |
| P20272 | |
| Q99NU2 |
| Unigene ID | Hs.75110 |
|---|---|
| Hs.709067 | |
| Mm.7992 | |
| Rn.89774 |
| KEGG ID | hsa:1268 |
|---|---|
| mmu:12801 | |
| rno:25248 |
| Swiss-Prot ID | CNR1_HUMAN |
|---|---|
| CNR1_MOUSE | |
| CNR1_RAT | |
| B2R9T4_HUMAN | |
| Q5JVL5_HUMAN | |
| B1AZT0_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004949 |
|---|---|
| 0004872 | |
| 0007187 | |
| 0007610 | |
| 0007165 | |
| 0005887 | |
| 0005886 | |
| 0004930 | |
| 0004871 | |
| 0007186 | |
| 0016021 | |
| 0016020 | |
| 0008144 |
| Pathway | CannabinoidR -> AP-1/EGR signaling |
|---|---|
| PPARbeta Targets |
| IPI ID | IPI00009396 |
|---|---|
| IPI00215993 | |
| IPI00655874 | |
| IPI00111245 | |
| IPI00197472 |
| Ariadne Ontology | GPCR-Gq-iCR |
|---|
| Mouse chromosome position | 4 13.9 cM |
|---|
| GO Molecular Function | drug binding |
|---|---|
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| cannabinoid receptor activity |
| Homologene ID | 7273 |
|---|
| Hugo ID | 2159 |
|---|
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MGI ID | 104615 |
|---|
| Human chromosome position | 6q14-q15 |
|---|
| GO Biological Process | signal transduction |
|---|---|
| G-protein coupled receptor protein signaling pathway | |
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| behavior |
| Rat chromosome position | 5q21 |
|---|
| Group | GPCR-Gq-iCR |
|---|---|
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| drug binding | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| cannabinoid receptor activity | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| G-protein signaling, coupled to cyclic nucleotide second messenger | |
| behavior |
| RGD ID | 2369 |
|---|
| LocusLink ID | 1268 |
|---|---|
| 12801 | |
| 25248 |
| Alias | CB1 |
|---|---|
| CNR | |
| CB-R | |
| CB1A | |
| CB1R | |
| CANN6 | |
| CB1K5 | |
| RP1-23D17.1 | |
| central cannabinoid receptor | |
| OTTHUMP00000016838 | |
| OTTHUMP00000016839 | |
| OTTHUMP00000016840 | |
| RP24-407G18.1 | |
| cannabinoid receptor 1 (brain) | |
| OTTMUSP00000008684 | |
| OTTMUSP00000008685 | |
| striatal cannabinoid receptor type 1 protein | |
| SKR6R | |
| Cannabinoid receptor 1 | |
| central cannabinoid receptor isoform b | |
| Cannabinoid receptor I | |
| CNR1 | |
| CNR I | |
| central cannabinoid receptor isoform a | |
| central cannabinoid receptors | |
| CB1-R | |
| CB1 receptor | |
| CB1 receptors | |
| cannabinoid CB1 receptor | |
| cannabinoid CB1 receptors | |
| CB1 cannabinoid receptor | |
| CB1 cannabinoid receptors | |
| cannabinoid receptor CB1 | |
| CB1-Rs | |
| LOC115733 | |
| LOC135303 | |
| LOC154309 | |
| LOC91814 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 114610 |
|---|