| URN | urn:agi-llid:1591 |
|---|---|
| Connectivity | 82 |
| Name | CYP24A1 |
| Description | cytochrome P450, family 24, subfamily A, polypeptide 1 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | VDR Targets |
|---|---|
| PXR Targets | |
| CAR Targets | |
| NR2C2 Targets |
| GO Molecular Function | electron carrier activity |
|---|---|
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| 25-hydroxycholecalciferol-24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | |
| 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity |
| GO Cellular Component | cellular_component |
|---|---|
| mitochondrion |
| GO Biological Process | vitamin D catabolic process |
|---|---|
| vitamin D metabolic process | |
| oxidation reduction |
| Group | cellular_component |
|---|---|
| mitochondrion | |
| electron carrier activity | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| 25-hydroxycholecalciferol-24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen | |
| 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity | |
| vitamin D catabolic process | |
| vitamin D metabolic process | |
| oxidation reduction |
| Hugo ID | 2602 |
|---|
| Human chromosome position | 20q13 |
|---|
| LocusLink ID | 1591 |
|---|---|
| 13081 | |
| 25279 |
| Alias | CP24 |
|---|---|
| CYP24 | |
| MGC126273 | |
| MGC126274 | |
| P450-CC24 | |
| cytochrome P450 family 24 subfamily A polypeptide 1 | |
| 24-OHase | |
| OTTHUMP00000031314 | |
| vitamin D 24-hydroxylase | |
| exo-mitochondrial protein | |
| 1,25-@dihydroxyvitamin D3 24-hydroxylase | |
| cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase) | |
| MGC129158 | |
| MGC129159 | |
| RP23-321D1.3 | |
| cytochrome P450, family 24, subfamily a, polypeptide 1 | |
| OTTMUSP00000017229 | |
| cytochrome P450, 24 | |
| cytochrome P450, 24a1 | |
| 25-hydroxyvitamin D-24-hydroxylase | |
| VITD12 | |
| 25-hydroxyvitaminD324-hydroxylase | |
| cytochrome P450, subfamily 24 | |
| 24R-Ohase | |
| 25-hydroxyvitamin D3 24-hydroxylase | |
| Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase) | |
| Cyp24a1 | |
| Cytochrome P450-CC24, mitochondrial precursor | |
| Vitamin D(3) 24-hydroxylase | |
| 25-hydroxyvitamin D24-hydroxylase | |
| cytochrome P450, family 24, subfamily A, polypeptide | |
| cytochrome P450, subfamily XXIV precursor | |
| cytochrome P450, family 24, subfamily A, polypeptide I | |
| cytochrome P450, family 24 precursor | |
| Cyp24a I | |
| mitochondrial Cytochrome P450-CC24 precursor | |
| 24 A1 | |
| VITD12s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 126065 |
|---|
| Swiss-Prot Accession | Q07973 |
|---|---|
| Q32ML3 | |
| Q5I2W7 | |
| Q3TWW0 | |
| Q64441 | |
| Q3TP55 | |
| Q3TWZ8 | |
| Q3TXU0 | |
| Q09128 |
| Unigene ID | Hs.89663 |
|---|---|
| Mm.6575 | |
| Rn.100353 |
| KEGG ID | hsa:1591 |
|---|---|
| mmu:13081 | |
| rno:25279 |
| EC Number | 1.14.-.- |
|---|
| Swiss-Prot ID | CP24A_HUMAN |
|---|---|
| CP24A_MOUSE | |
| CP24A_RAT | |
| Q32ML3_HUMAN | |
| Q3TWW0_MOUSE |
| GO ID | 0030342 |
|---|---|
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0016709 | |
| 0055114 | |
| 0005575 | |
| 0005739 | |
| 0008403 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0042359 | |
| 0042369 |
| IPI ID | IPI00020586 |
|---|---|
| IPI00656023 | |
| IPI00796070 | |
| IPI00221624 | |
| IPI00559048 |
| Mouse chromosome position | 2 99.0 cM |
|---|
| Homologene ID | 68094 |
|---|
| MGI ID | 88593 |
|---|
| Rat chromosome position | 3q42 |
|---|
| RGD ID | 2462 |
|---|