| URN | urn:agi-llid:11221 |
|---|---|
| Connectivity | 37 |
| Name | DUSP10 |
| Description | dual specificity phosphatase 10 |
| Notes | Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | VDR Targets |
|---|
| Ariadne Ontology | DUSP |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| hydrolase activity | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity | |
| MAP kinase tyrosine-serine-threonine phosphatase activity |
| GO Cellular Component | cellular_component |
|---|---|
| cytoplasm | |
| nucleus |
| GO Biological Process | JNK cascade |
|---|---|
| protein amino acid dephosphorylation | |
| dephosphorylation | |
| response to stress | |
| response to organic substance |
| Group | DUSP |
|---|---|
| cellular_component | |
| cytoplasm | |
| nucleus | |
| molecular_function | |
| hydrolase activity | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity | |
| MAP kinase tyrosine-serine-threonine phosphatase activity | |
| JNK cascade | |
| protein amino acid dephosphorylation | |
| dephosphorylation | |
| response to stress | |
| response to organic substance |
| Hugo ID | 3065 |
|---|
| Human chromosome position | 1q41 |
|---|
| LocusLink ID | 11221 |
|---|---|
| 63953 | |
| 63995 |
| Alias | MKP5 |
|---|---|
| MKP-5 | |
| dual specificity phosphatase 10 | |
| OTTHUMP00000035380 | |
| map kinase phosphatase 5 | |
| dual specificity phosphatase MKP-5 | |
| serine/threonine specific protein phosphatase | |
| AI158871 | |
| 2610306G15Rik | |
| dual specificity phosphatase MKP V | |
| MKP V | |
| DUSP10 | |
| map kinase phosphatase V | |
| 2610306G15Rik(2) | |
| LOC289347 | |
| RIKEN cDNA 2610306G15 gene | |
| DUSP10s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608867 |
|---|
| Swiss-Prot Accession | Q9Y6W6 |
|---|---|
| Q6IAR2 | |
| Q8R3L3 | |
| Q9CSL5 | |
| Q9ESS0 |
| Unigene ID | Hs.497822 |
|---|---|
| Mm.404024 | |
| Rn.163239 |
| KEGG ID | hsa:11221 |
|---|---|
| mmu:63953 | |
| rno:63995 |
| EC Number | 3.1.3.48 |
|---|---|
| 3.1.3.16 |
| Swiss-Prot ID | DUS10_HUMAN |
|---|---|
| Q8R3L3_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0017017 |
|---|---|
| 0016787 | |
| 0004725 | |
| 0007254 | |
| 0006470 | |
| 0006950 | |
| 0005737 | |
| 0005634 | |
| 0016791 | |
| 0004721 | |
| 0008138 | |
| 0016311 | |
| 0003674 | |
| 0010033 | |
| 0005575 |
| IPI ID | IPI00026987 |
|---|---|
| IPI00158733 | |
| IPI00113513 | |
| IPI00331627 | |
| IPI00363396 |
| Mouse chromosome position | 1 H5 |
|---|
| Homologene ID | 5215 |
|---|
| MGI ID | 1927070 |
|---|
| RGD ID | 1310844 |
|---|