| URN | urn:agi-llid:51141 |
|---|---|
| Connectivity | 43 |
| Name | INSIG2 |
| Description | insulin induced gene 2 |
| Notes | The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq] |
| Pathway | LXRA Targets |
|---|---|
| VDR Targets |
| GO Molecular Function | protein binding |
|---|---|
| transcription factor binding |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane |
| GO Biological Process | cholesterol metabolic process |
|---|---|
| steroid metabolic process | |
| lipid metabolic process | |
| response to sterol depletion |
| Group | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| integral to membrane | |
| protein binding | |
| transcription factor binding | |
| cholesterol metabolic process | |
| steroid metabolic process | |
| lipid metabolic process | |
| response to sterol depletion |
| Hugo ID | 20452 |
|---|
| Human chromosome position | 2q14.1 |
|---|
| LocusLink ID | 51141 |
|---|---|
| 72999 | |
| 288985 |
| Alias | MGC26273 |
|---|---|
| insulin induced protein 2 | |
| INSIG2 membrane protein | |
| Insig-2 | |
| 2900053I11Rik | |
| C730043J18Rik | |
| INSIG-2 membrane protein | |
| insulin induced gene 2 | |
| growth response protein (CL-6) | |
| insulin induced gene II | |
| INSIG2 | |
| RIKEN cDNA C730043J18 gene | |
| LOC129941 | |
| LOC150813 | |
| LOC51141 | |
| LOC64194 | |
| INSIG2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608660 |
|---|
| Swiss-Prot Accession | A8K5W8 |
|---|---|
| Q9Y5U4 | |
| Q91WG1 | |
| Q80UA9 |
| Unigene ID | Hs.7089 |
|---|---|
| Mm.27136 | |
| Rn.16736 |
| KEGG ID | hsa:51141 |
|---|---|
| mmu:72999 | |
| rno:288985 |
| Swiss-Prot ID | INSI2_HUMAN |
|---|---|
| INSI2_MOUSE | |
| INSI2_RAT | |
| A8K5W8_HUMAN |
| GO ID | 0005515 |
|---|---|
| 0008203 | |
| 0006629 | |
| 0006991 | |
| 0008202 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0008134 |
| IPI ID | IPI00001794 |
|---|---|
| IPI00413159 | |
| IPI00459467 | |
| IPI00287193 |
| Mouse chromosome position | 1 E2 |
|---|
| Homologene ID | 9400 |
|---|
| MGI ID | 1920249 |
|---|
| Rat chromosome position | 13q11 |
|---|
| RGD ID | 631417 |
|---|