| URN | urn:agi-llid:1437 |
|---|---|
| Name | CSF2 |
| Description | colony stimulating factor 2 (granulocyte-macrophage) |
| Connectivity | 1441 |
| Notes | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq] |
| Swiss-Prot Accession | P04141 |
|---|---|
| Q647J8 | |
| P01587 | |
| Q5SX78 | |
| Q14AD9 | |
| P48750 |
| Unigene ID | Hs.1349 |
|---|---|
| Mm.4922 | |
| Rn.44285 |
| KEGG ID | hsa:1437 |
|---|---|
| mmu:12981 | |
| rno:116630 |
| Swiss-Prot ID | CSF2_HUMAN |
|---|---|
| CSF2_MOUSE | |
| CSF2_RAT | |
| Q5SX78_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005129 | |
| 0005515 | |
| 0006955 | |
| 0043011 | |
| 0043066 | |
| 0045918 | |
| 0045740 | |
| 0008284 | |
| 0010744 | |
| 0045885 | |
| 0042523 | |
| 0005576 | |
| 0005615 | |
| 0008083 | |
| 0042127 | |
| 0010468 | |
| 0050673 | |
| 0042045 | |
| 0045651 |
| Pathway | CSF2R -> STAT signaling |
|---|---|
| CSF2R -> NF-kB signaling | |
| VDR Targets |
| IPI ID | IPI00022270 |
|---|---|
| IPI00323907 | |
| IPI00372574 |
| Ariadne Ontology | Cytokine |
|---|
| Mouse chromosome position | 11 29.5 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| growth factor activity | |
| cytokine activity | |
| granulocyte macrophage colony-stimulating factor receptor binding |
| Homologene ID | 600 |
|---|
| Hugo ID | 2434 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| MGI ID | 1339752 |
|---|
| Human chromosome position | 5q31.1 |
|---|
| GO Biological Process | negative regulation of cytolysis |
|---|---|
| negative regulation of apoptosis | |
| positive regulation of survival gene product expression | |
| positive regulation of cell proliferation | |
| positive regulation of tyrosine phosphorylation of Stat5 protein | |
| positive regulation of macrophage differentiation | |
| positive regulation of foam cell differentiation | |
| positive regulation of DNA replication | |
| regulation of cell proliferation | |
| regulation of gene expression | |
| myeloid dendritic cell differentiation | |
| epithelial cell proliferation | |
| epithelial fluid transport | |
| immune response |
| Rat chromosome position | 10q22 |
|---|
| Group | Cytokine |
|---|---|
| extracellular region | |
| extracellular space | |
| protein binding | |
| growth factor activity | |
| cytokine activity | |
| granulocyte macrophage colony-stimulating factor receptor binding | |
| negative regulation of cytolysis | |
| negative regulation of apoptosis | |
| positive regulation of survival gene product expression | |
| positive regulation of cell proliferation | |
| positive regulation of tyrosine phosphorylation of Stat5 protein | |
| positive regulation of macrophage differentiation | |
| positive regulation of foam cell differentiation | |
| positive regulation of DNA replication | |
| regulation of cell proliferation | |
| regulation of gene expression | |
| myeloid dendritic cell differentiation | |
| epithelial cell proliferation | |
| epithelial fluid transport | |
| immune response |
| RGD ID | 621065 |
|---|
| LocusLink ID | 1437 |
|---|---|
| 12981 | |
| 116630 |
| Alias | GMCSF |
|---|---|
| MGC131935 | |
| MGC138897 | |
| colony stimulating factor 2 | |
| molgramostin | |
| sargramostim | |
| granulocyte-macrophage colony stimulating factor | |
| Csfgm | |
| Gm-CSf | |
| MGI-IGM | |
| MGC151255 | |
| MGC151257 | |
| put. GM-CSF | |
| OTTMUSP00000005830 | |
| granulocyte-macrophage colony stimulating factor 2 | |
| colony stimulation factor 2 (granulocyte-macrophage) | |
| colony stimulation factor 2 precursor | |
| granulocyte-macrophage colony stimulation factor | |
| colony stimulating factor 2 precursor | |
| Csf2 | |
| CSF2_HUMAN | |
| colony stimulating factor 2 (granulocyte-macrophage) | |
| leukine | |
| rhu gm-csf |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138960 |
|---|