Protein IL4

URN	urn:agi-llid:3565
Connectivity	1918
Name	IL4
Description	interleukin 4
Notes	The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]

Pathway	IL4R -> ELK-SRF/HMGY signaling
	IL4R -> STAT signaling
	Common Regulators
	PPARA Targets
	VDR Targets
	ERA Pathway
	ERB Targets
	Common Regulators and Small Molecules

Ariadne Ontology	Cytokine

GO Molecular Function	protein binding
	growth factor activity
	cytokine activity
	hematopoietin-interferon-class (D200-domain) cytokine receptor binding
	interleukin-4 receptor binding

GO Cellular Component	extracellular region
	extracellular space

GO Biological Process	negative regulation of apoptosis
	negative regulation of osteoclast differentiation
	positive regulation of B cell activation
	positive regulation of B cell proliferation
	positive regulation of isotype switching to IgE isotypes
	positive regulation of isotype switching to IgG isotypes
	positive regulation of T cell proliferation
	positive regulation of activated T cell proliferation
	positive regulation of tyrosine phosphorylation of Stat5 protein
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of peptidyl-tyrosine phosphorylation
	positive regulation of MHC class II biosynthetic process
	regulation of isotype switching
	regulation of phosphorylation
	regulation of immune response
	B cell activation
	B cell differentiation
	cholesterol metabolic process
	connective tissue growth factor biosynthetic process
	immune response
	T-helper 2 type immune response
	chemotaxis
	inflammatory response
	cellular defense response

Group	Cytokine
	extracellular region
	extracellular space
	protein binding
	growth factor activity
	cytokine activity
	hematopoietin-interferon-class (D200-domain) cytokine receptor binding
	interleukin-4 receptor binding
	negative regulation of apoptosis
	negative regulation of osteoclast differentiation
	positive regulation of B cell activation
	positive regulation of B cell proliferation
	positive regulation of isotype switching to IgE isotypes
	positive regulation of isotype switching to IgG isotypes
	positive regulation of T cell proliferation
	positive regulation of activated T cell proliferation
	positive regulation of tyrosine phosphorylation of Stat5 protein
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of peptidyl-tyrosine phosphorylation
	positive regulation of MHC class II biosynthetic process
	regulation of isotype switching
	regulation of phosphorylation
	regulation of immune response
	B cell activation
	B cell differentiation
	cholesterol metabolic process
	connective tissue growth factor biosynthetic process
	immune response
	T-helper 2 type immune response
	chemotaxis
	inflammatory response
	cellular defense response

Hugo ID	6014

Human chromosome position	5q31.1

Alias	BSF1
	IL-4
	BCGF1
	BCGF-1
	MGC79402
	interleukin 4
	B cell growth factor 1
	B_cell stimulatory factor 1
	lymphocyte stimulatory factor 1
	RP23-188H3.4
	OTTMUSP00000005817
	Il4e12
	BSF-1
	IL4_HUMAN
	interleukin IV
	B-cell stimulatory factor I
	Interleukin-IL4
	Lymphocyte stimulatory factor I
	IL IV
	BSF I
	IL4
	IL[4]
	interleukin[4]
	B-cell stimulatory factor 1

OMIM ID	147780

Cell Localization	Extracellular

Mouse chromosome position	11 29.0 cM

Homologene ID	491

MGI ID	96556

Rat chromosome position	10q22

RGD ID	2898