| URN | urn:agi-llid:3684 |
|---|---|
| Connectivity | 589 |
| Name | ITGAM |
| Description | integrin, alpha M (complement component 3 receptor 3 subunit) |
| Notes | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | MacrophageR -> CEBPB/NF-kB signaling |
|---|---|
| RARA Targets | |
| VDR Targets | |
| TR3 Targets | |
| NR4A3 Targets |
| Ariadne Ontology | ITG |
|---|
| GO Molecular Function | protein binding |
|---|---|
| heparin binding | |
| calcium ion binding | |
| magnesium ion binding | |
| opsonin binding | |
| glycoprotein binding | |
| heparan sulfate proteoglycan binding | |
| protein heterodimerization activity | |
| receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| external side of plasma membrane | |
| cytoplasm | |
| Golgi apparatus | |
| nucleus | |
| integral to membrane | |
| integrin complex |
| GO Biological Process | cell adhesion |
|---|---|
| leukocyte adhesion | |
| integrin-mediated signaling pathway | |
| activated T cell proliferation | |
| neutrophil chemotaxis | |
| cellular extravasation |
| Group | ITG |
|---|---|
| cell surface | |
| membrane | |
| external side of plasma membrane | |
| cytoplasm | |
| Golgi apparatus | |
| nucleus | |
| integral to membrane | |
| integrin complex | |
| protein binding | |
| heparin binding | |
| calcium ion binding | |
| magnesium ion binding | |
| opsonin binding | |
| glycoprotein binding | |
| heparan sulfate proteoglycan binding | |
| protein heterodimerization activity | |
| receptor activity | |
| cell adhesion | |
| leukocyte adhesion | |
| integrin-mediated signaling pathway | |
| activated T cell proliferation | |
| neutrophil chemotaxis | |
| cellular extravasation |
| Hugo ID | 6149 |
|---|
| Human chromosome position | 16p11.2 |
|---|
| LocusLink ID | 3684 |
|---|---|
| 16409 | |
| 25021 |
| Alias | CR3A |
|---|---|
| MO1A | |
| CD11B | |
| MAC-1 | |
| MAC1A | |
| SLEB6 | |
| MGC117044 | |
| integrin alpha M | |
| antigen CD11b (p170) | |
| macrophage antigen alpha polypeptide | |
| neutrophil adherence receptor alpha-M subunit | |
| CR3 | |
| MAC1 | |
| Ly-40 | |
| Mac-1a | |
| CD11b/CD18 | |
| F730045J24Rik | |
| Mac-1 alpha | |
| CD11B (p170) | |
| macrophage antigen alpha | |
| complement receptor type 3 | |
| leukocyte adhesion receptor MO1 | |
| complement component receptor 3 alpha | |
| complement component receptor 3 alpha-a | |
| cell surface glycoprotein MAC-1 alpha subunit | |
| Integrin alpha-M | |
| CR3 receptor | |
| alpha m integrin | |
| CR3 receptors | |
| Cell surface glycoprotein MAC-1 alpha subunit | |
| complement component receptor 3, alpha | |
| integrin alpha M (Cd11b) | |
| Integrin alpha-M precursor | |
| Itgam | |
| antigen CD11b | |
| integrin beta 2 alpha subunit, CD11b | |
| complement component receptor 3 | |
| complement component receptor III | |
| complement receptor type III | |
| CR-3 alpha | |
| complement component receptor 3 alpha-a (CR3A) | |
| CR3 protein | |
| Integrin, alpha-M (complement component receptor-3, alpha; antigen CD11B (p170); macrophage antigen, alpha polypeptide) | |
| LOC256912 | |
| antigen CD11b | |
| integrin, alpha M (complement component 3 receptor 3 subunit) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 120980 |
|---|---|
| 609939 |
| Swiss-Prot Accession | P11215 |
|---|---|
| Q4VAK1 | |
| P05555 | |
| Q3TBT0 | |
| Q3TD86 | |
| Q3U1U4 | |
| Q3U1W4 | |
| Q3U3F0 | |
| Q3U4I5 | |
| Q3UJ88 | |
| Q9JI30 | |
| Q63001 |
| Unigene ID | Hs.172631 |
|---|---|
| Mm.262106 | |
| Rn.54465 |
| KEGG ID | hsa:3684 |
|---|---|
| rno:25021 |
| Swiss-Prot ID | ITAM_HUMAN |
|---|---|
| Q9JI30_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005509 |
|---|---|
| 0001948 | |
| 0000287 | |
| 0046982 | |
| 0004872 | |
| 0007155 | |
| 0007229 | |
| 0005794 | |
| 0005737 | |
| 0016021 | |
| 0008305 | |
| 0016020 | |
| 0005634 | |
| 0043395 | |
| 0008201 | |
| 0001846 | |
| 0005515 | |
| 0050798 | |
| 0045123 | |
| 0007159 | |
| 0030593 | |
| 0009986 | |
| 0009897 |
| IPI ID | IPI00217987 |
|---|---|
| IPI00645887 | |
| IPI00646708 | |
| IPI00415773 | |
| IPI00120674 | |
| IPI00876475 | |
| IPI00761784 | |
| IPI00886282 | |
| IPI00885645 | |
| IPI00885562 | |
| IPI00886087 | |
| IPI00199853 | |
| IPI00781657 |
| Mouse chromosome position | 7 F4 |
|---|
| Homologene ID | 526 |
|---|
| MGI ID | 96607 |
|---|
| Rat chromosome position | 1q36 |
|---|
| RGD ID | 2926 |
|---|