| URN | urn:agi-llid:2064 |
|---|---|
| Connectivity | 859 |
| Name | ERBB2 |
| Description | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
| Notes | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq] |
| Pathway | IL6ST -> STAT5B signaling |
|---|---|
| EGFR/ERBB -> STAT signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| Common Regulators | |
| VDR Targets | |
| ERB Targets |
| Ariadne Ontology | Oncogenes |
|---|---|
| GFR |
| GO Molecular Function | protein binding |
|---|---|
| nucleotide binding | |
| ATP binding | |
| glycoprotein binding | |
| growth factor binding | |
| identical protein binding | |
| ubiquitin protein ligase binding | |
| protein phosphatase binding | |
| Hsp90 protein binding | |
| protein heterodimerization activity | |
| ErbB-3 class receptor binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| epidermal growth factor receptor activity | |
| receptor activity | |
| transmembrane receptor activity |
| GO Cellular Component | membrane |
|---|---|
| apical plasma membrane | |
| basal plasma membrane | |
| microvillus | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| nucleus | |
| plasma membrane | |
| postsynaptic membrane | |
| membrane raft | |
| integral to membrane | |
| basolateral plasma membrane | |
| lateral loop | |
| receptor complex |
| GO Biological Process | regulation of angiogenesis |
|---|---|
| positive regulation of cell adhesion | |
| negative regulation of immature T cell proliferation in the thymus | |
| negative regulation of apoptosis | |
| positive regulation of cell proliferation | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| positive regulation of MAPKKK cascade | |
| positive regulation of Ras protein signal transduction | |
| positive regulation of epithelial cell proliferation | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| positive regulation of MAP kinase activity | |
| cell surface receptor linked signal transduction | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| phosphoinositide 3-kinase cascade | |
| phosphoinositide-mediated signaling | |
| myelination | |
| cell proliferation | |
| motor axon guidance | |
| neuromuscular junction development | |
| glial cell differentiation | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| mammary gland involution | |
| heart development | |
| liver development | |
| mammary gland development | |
| skeletal muscle tissue development | |
| tongue development | |
| nervous system development | |
| central nervous system development | |
| peripheral nervous system development | |
| sympathetic nervous system development | |
| estrus | |
| response to drug | |
| response to progesterone stimulus | |
| response to axon injury | |
| wound healing |
| Group | Oncogenes |
|---|---|
| GFR | |
| membrane | |
| apical plasma membrane | |
| basal plasma membrane | |
| microvillus | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| nucleus | |
| plasma membrane | |
| postsynaptic membrane | |
| membrane raft | |
| integral to membrane | |
| basolateral plasma membrane | |
| lateral loop | |
| receptor complex | |
| protein binding | |
| nucleotide binding | |
| ATP binding | |
| glycoprotein binding | |
| growth factor binding | |
| identical protein binding | |
| ubiquitin protein ligase binding | |
| protein phosphatase binding | |
| Hsp90 protein binding | |
| protein heterodimerization activity | |
| ErbB-3 class receptor binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor signaling protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| epidermal growth factor receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| regulation of angiogenesis | |
| positive regulation of cell adhesion | |
| negative regulation of immature T cell proliferation in the thymus | |
| negative regulation of apoptosis | |
| positive regulation of cell proliferation | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| positive regulation of MAPKKK cascade | |
| positive regulation of Ras protein signal transduction | |
| positive regulation of epithelial cell proliferation | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| positive regulation of MAP kinase activity | |
| cell surface receptor linked signal transduction | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| phosphoinositide 3-kinase cascade | |
| phosphoinositide-mediated signaling | |
| myelination | |
| cell proliferation | |
| motor axon guidance | |
| neuromuscular junction development | |
| glial cell differentiation | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| mammary gland involution | |
| heart development | |
| liver development | |
| mammary gland development | |
| skeletal muscle tissue development | |
| tongue development | |
| nervous system development | |
| central nervous system development | |
| peripheral nervous system development | |
| sympathetic nervous system development | |
| estrus | |
| response to drug | |
| response to progesterone stimulus | |
| response to axon injury | |
| wound healing |
| Hugo ID | 3430 |
|---|
| Human chromosome position | 17q11.2-q12 |
|---|
| LocusLink ID | 2064 |
|---|---|
| 13866 | |
| 24337 |
| Alias | NEU |
|---|---|
| NGL | |
| HER2 | |
| TKR1 | |
| CD340 | |
| HER-2 | |
| HER-2/neu | |
| erbB-2 | |
| herstatin | |
| c-erb B2/neu protein | |
| neuroblastoma/glioblastoma derived oncogene homolog | |
| v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) | |
| c-neu | |
| c-erbB2 | |
| mKIAA3023 | |
| RP23-355L10.8 | |
| v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | |
| Neu oncogene | |
| OTTMUSP00000002540 | |
| avian erythroblastosis oncogene B 2 | |
| Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) | |
| Erb-b2 | |
| v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 | |
| v-erb-b2 erythroblastic leukemia viral oncogene homolog II | |
| HER2/neu | |
| v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | |
| v-erb-b2 avian erythroblastic leukemia viral oncogene homolog II | |
| tyrosine kinase-type cell surface receptor | |
| avian erythroblastosis viral (v-erb-b2) oncogene homologue 2 | |
| avian erythroblastosis viral (v-erb-b2) oncogene homologue II | |
| ERB2 | |
| Erbb2 | |
| HER2 kinase | |
| MLN 19 | |
| NEU proto-oncogene | |
| p185erbB2 | |
| protein-tyrosine kinase erbB2 precursor | |
| Receptor protein-tyrosine kinase ERBB-2 precursor | |
| Tyrosine kinase-type cell surface receptor HER2 | |
| Avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 2 | |
| Avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog II | |
| ERB2_HUMAN | |
| v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glio | |
| v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblasto | |
| avian erythroblastosis oncogene B II | |
| C-erbB II | |
| TKR I | |
| v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | |
| c-erb b2 | |
| C-erbB-2 | |
| Erb-b2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 164870 |
|---|---|
| 211980 | |
| 137215 | |
| 137800 |
| Swiss-Prot Accession | P04626 |
|---|---|
| B2RZG3 | |
| Q4H1F1 | |
| Q4H1F2 | |
| Q9NP09 | |
| Q9UK79 | |
| A2A557 | |
| P70424 | |
| Q08615 | |
| Q80Y89 | |
| Q8C0E7 | |
| Q8R2X1 | |
| Q8K3F9 | |
| P06494 | |
| Q63365 | |
| Q923V5 |
| Unigene ID | Hs.446352 |
|---|---|
| Mm.290822 | |
| Mm.406337 | |
| Rn.93966 |
| KEGG ID | mmu:13866 |
|---|---|
| rno:24337 |
| EC Number | 2.7.10.1 |
|---|
| Swiss-Prot ID | ERBB2_HUMAN |
|---|---|
| ERBB2_MOUSE | |
| B2RZG3_HUMAN | |
| A2A557_MOUSE | |
| Q8K3F9_RAT |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005524 |
|---|---|
| 0043125 | |
| 0005006 | |
| 0019838 | |
| 0042802 | |
| 0000166 | |
| 0046982 | |
| 0019903 | |
| 0004716 | |
| 0016740 | |
| 0004888 | |
| 0008283 | |
| 0007507 | |
| 0030879 | |
| 0008045 | |
| 0042552 | |
| 0033088 | |
| 0007528 | |
| 0007422 | |
| 0014065 | |
| 0048015 | |
| 0043406 | |
| 0045785 | |
| 0050679 | |
| 0046777 | |
| 0045765 | |
| 0007169 | |
| 0042060 | |
| 0016324 | |
| 0016323 | |
| 0005737 | |
| 0016021 | |
| 0005886 | |
| 0043235 | |
| 0016301 | |
| 0004672 | |
| 0004713 | |
| 0004872 | |
| 0004714 | |
| 0007166 | |
| 0007399 | |
| 0006468 | |
| 0016020 | |
| 0051879 | |
| 0001948 | |
| 0005515 | |
| 0031625 | |
| 0007417 | |
| 0060209 | |
| 0010001 | |
| 0001889 | |
| 0060056 | |
| 0043066 | |
| 0043410 | |
| 0046579 | |
| 0008284 | |
| 0014068 | |
| 0045595 | |
| 0042127 | |
| 0048678 | |
| 0042493 | |
| 0032570 | |
| 0007519 | |
| 0048485 | |
| 0043586 | |
| 0009925 | |
| 0043219 | |
| 0045121 | |
| 0005902 | |
| 0005634 | |
| 0048471 | |
| 0045211 |
| IPI ID | IPI00300384 |
|---|---|
| IPI00845478 | |
| IPI00384288 | |
| IPI00626433 | |
| IPI00473769 | |
| IPI00325943 | |
| IPI00882414 | |
| IPI00557331 | |
| IPI00780901 | |
| IPI00567071 |
| Mouse chromosome position | 11 57.0 cM |
|---|
| Homologene ID | 3273 |
|---|
| MGI ID | 95410 |
|---|
| Rat chromosome position | 10q32.1 |
|---|
| RGD ID | 2561 |
|---|