Protein CDKN1A

URN	urn:agi-llid:1026
Name	CDKN1A
Description	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Connectivity	978
Notes	This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.

Cell Localization	Cytoplasm

Pathway	PPARG Targets
	VDR Targets

Ariadne Ontology	CDKN

Mouse chromosome position	17 15.23 cM

GO Molecular Function	protein binding
	metal ion binding
	zinc ion binding
	protein complex binding
	cyclin binding
	kinase activity
	protein kinase inhibitor activity
	cyclin-dependent protein kinase inhibitor activity

Homologene ID	333

Hugo ID	1784

GO Cellular Component	cytoplasm
	cyclin-dependent protein kinase holoenzyme complex
	cytosol
	nucleus
	nucleoplasm

MGI ID	104556

Human chromosome position	6p21.2

GO Biological Process	negative regulation of cell proliferation
	negative regulation of cell growth
	negative regulation of cyclin-dependent protein kinase activity
	negative regulation of apoptosis
	positive regulation of anti-apoptosis
	negative regulation of phosphorylation
	positive regulation of B cell proliferation
	positive regulation of programmed cell death
	induction of apoptosis by intracellular signals
	positive regulation of fibroblast proliferation
	regulation of cell cycle
	cell cycle
	cellular response to extracellular stimulus
	cell cycle arrest
	G1-S transition of mitotic cell cycle
	G2-M transition of mitotic cell cycle
	organ regeneration
	response to UV
	response to drug
	response to organic substance
	response to toxin
	response to glucocorticoid stimulus
	response to corticosterone stimulus
	response to arsenic
	response to organic nitrogen
	response to organic cyclic substance
	response to hyperoxia
	response to DNA damage stimulus

Rat chromosome position	20p12

Group	CDKN
	cytoplasm
	cyclin-dependent protein kinase holoenzyme complex
	cytosol
	nucleus
	nucleoplasm
	protein binding
	metal ion binding
	zinc ion binding
	protein complex binding
	cyclin binding
	kinase activity
	protein kinase inhibitor activity
	cyclin-dependent protein kinase inhibitor activity
	negative regulation of cell proliferation
	negative regulation of cell growth
	negative regulation of cyclin-dependent protein kinase activity
	negative regulation of apoptosis
	positive regulation of anti-apoptosis
	negative regulation of phosphorylation
	positive regulation of B cell proliferation
	positive regulation of programmed cell death
	induction of apoptosis by intracellular signals
	positive regulation of fibroblast proliferation
	regulation of cell cycle
	cell cycle
	cellular response to extracellular stimulus
	cell cycle arrest
	G1-S transition of mitotic cell cycle
	G2-M transition of mitotic cell cycle
	organ regeneration
	response to UV
	response to drug
	response to organic substance
	response to toxin
	response to glucocorticoid stimulus
	response to corticosterone stimulus
	response to arsenic
	response to organic nitrogen
	response to organic cyclic substance
	response to hyperoxia
	response to DNA damage stimulus

RGD ID	69328

Alias	P21
	CIP1
	SDI1
	WAF1
	CAP20
	CDKN1
	MDA-6
	p21CIP1
	cyclin-dependent kinase inhibitor 1A
	p21Cip1/Waf1
	OTTHUMP00000016298
	DNA synthesis inhibitor
	CDK-interaction protein 1
	wild-type p53-activated fragment 1
	melanoma differentiation associated protein 6
	CDKI
	mda6
	p21WAF
	cyclin-dependent kinase inhibitor 1A (P21)
	p21<WAF1/CIP1>
	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
	p21/Cip1/Waf1
	p21/Waf-1
	p21/Waf-1/Cip1
	p21 Cip1/Waf1/Sic1
	Cyclin-dependent kinase inhibitor I
	wild-type p53-activated fragment I
	CDK-interaction protein I
	CDK-interacting protein 1
	CDK-interacting protein I
	SDI I
	CDKN I
	p21/Cip1/Waf I
	WAF I
	MDA VI
	p21/Waf I
	CipI/WafI
	cyclin-dependent kinase inhibitor P21 Cip1/Waf1
	p21/Cip1/Waf1/SDI1
	Cip1/Waf1
	Waf-1/Cip1
	Cdkn1a
	p21/Cip
	cyclin-dependent kinase inhibitor P21
	CDN1_HUMAN
	melanoma differentiating associated protein 6
	melanoma differentiating associated protein VI
	CDK-interactive protein I
	CDK-interactive protein 1
	p21/Waf-1/Cip I
	melanoma differentiation associated protein VI
	p21/Cip I
	p21 WAF1/CIP1
	p21/Cip1
	WAF1/Clip1
	p21(WAF/CLIP1)
	WAF/CLIP1
	P(21)

OMIM ID	116899